ArticlePloS one2014
Asthma trajectories in early childhood: identifying modifiable factors.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation.The journal of allergy and clinical immunology. In practice · 2019Trial
- Respiratory morbidity at age 4 across COVID-19 and pre-pandemic birth cohorts: the role of atopic risk.European journal of pediatrics · 2026Article
- Social inequalities in childhood asthma.The World Allergy Organization journal · 2024Review
- Plasma metabolomics identifies differing endotypes of recurrent wheezing in preschool children differentiated by symptoms and social disadvantage.Scientific reports · 2024Article
- Using large administrative data for mining patients' trajectories for risk stratification: An example from urological diseases.PloS one · 2024Article
- Socioeconomic position, bronchiolitis and asthma in children: counterfactual disparity measures from a national birth cohort study.International journal of epidemiology · 2023Article
- Early-Life Antibiotic Exposure and Childhood Asthma Trajectories: A National Population-Based Birth Cohort.Antibiotics (Basel, Switzerland) · 2023Article
- Trajectories of neighborhood environmental factors and their associations with asthma symptom trajectories among children in Australia: evidence from a national birth cohort study.Journal of environmental health science & engineering · 2022Article
- Early-life residential exposure to moisture damage is associated with persistent wheezing in a Finnish birth cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Asthma clustering methods: a literature-informed application to the children's health study data.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Review
- Article
- Defining pediatric asthma: phenotypes to endotypes and beyond.Pediatric research · 2021Review
- Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association with 1-Year Outcomes.The journal of allergy and clinical immunology. In practice · 2020Article
- Understanding the dynamics of asthma symptoms between childhood and adolescence using latent transition analysis.International journal of public health · 2020Article
- Many Kinds of Poverty: Three Dimensions of Economic Hardship, Their Combinations, and Children's Behavior Problems.Demography · 2019Article
- Home environment: respiratory and allergic phenotypes from birth to age six in the PELAGIE cohort.NPJ primary care respiratory medicine · 2019Article
- Comparison of the Associations of Early-Life Factors on Wheezing Phenotypes in Preterm-Born Children and Term-Born Children.American journal of epidemiology · 2019Article
- Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort.American journal of respiratory and critical care medicine · 2019Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are conflicting views as to whether childhood wheezing represents several discreet entities or a single but variable disease. Classification has centered on phenotypes often derived using subjective criteria, small samples, and/or with little data for young children. This is particularly problematic as asthmatic features appear to be entrenched by age 6/7. In this paper we aim to: identify longitudinal trajectories of wheeze and other atopic symptoms in early childhood; characterize the resulting trajectories by the socio-economic background of children; and identify potentially modifiable processes in infancy correlated with these trajectories. DATA AND
methodsThe Millennium Cohort Study is a large, representative birth cohort of British children born in 2000-2002. Our analytical sample includes 11,632 children with data on key variables (wheeze in the last year; ever hay-fever and/or eczema) reported by the main carers at age 3, 5 and 7 using a validated tool, the International Study of Asthma and Allergies in Childhood module. We employ longitudinal Latent Class Analysis, a clustering methodology which identifies classes underlying the observed population heterogeneity.
resultsOur model distinguished four latent trajectories: a trajectory with both low levels of wheeze and other atopic symptoms (54% of the sample); a trajectory with low levels of wheeze but high prevalence of other atopic symptoms (29%); a trajectory with high prevalence of both wheeze and other atopic symptoms (9%); and a trajectory with high levels of wheeze but low levels of other atopic symptoms (8%). These groups differed in terms of socio-economic markers and potential intervenable factors, including household damp and breastfeeding initiation.
conclusionUsing data-driven techniques, we derived four trajectories of asthmatic symptoms in early childhood in a large, population based sample. These groups differ in terms of their socio-economic profiles. We identified correlated intervenable pathways in infancy, including household damp and breastfeeding initiation.
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