Evidence map›Paper›PMID 25379623›Full record

SynthesisPublic health nutrition2015

Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis.

Seyede-Masome Derakhshande-Rishehri, Marjan Mansourian, Roya Kelishadi, Motahar Heidari-Beni

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Public health nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04728399 (Effects of Soy Peptide and Conjugated Linoleic Acid on Body Composition), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04728399 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effects of Soy Peptide and Conjugated Linoleic Acid on Body Composition: a Double-blind, Randomized, Placebo-controlled Clinical Trial

TypeinterventionalSponsorFangfang ZengRan2021 to 2022Enrolled120ConditionsOverweight or ObesityArmsExperimental group, Control group
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  10. Production of Conjugated Linoleic Acid (CLA) byFoods (Basel, Switzerland) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Seyede-Masome Derakhshande-Rishehri1Food Security Research Center,Department of Clinical Nutrition,School of Nutrition & Food Sciences,Isfahan University of Medical Sciences,Isfahan,Islamic Republic of Iran.
Marjan Mansourian2Department of Biostatistics and Epidemiology,School of Health,Isfahan University of Medical Sciences,Isfahan,Islamic Republic of Iran.
Roya Kelishadi3Child Growth and Development Research Center,Research Institute for Primary Prevention of Non-communicable Disease,Isfahan University of Medical Sciences,Isfahan,Islamic Republic of Iran.
Motahar Heidari-Beni4Food Security Research Center,Department of Community Nutrition,School of Nutrition & Food Sciences,Isfahan University of Medical Sciences,Isfahan 81754,Islamic Republic of Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present study aimed to review the association of conjugated linoleic acid (CLA) consumption in two forms, foods enriched in CLA and CLA supplements, with serum lipid profile in human studies.

designSystematic review and meta-analysis.

settingSearch process was conducted in PubMed, Cochrane Library, Google Scholar, Scopus and Science Direct. Clinical trials that investigated the association of CLA intakes either in the form of supplements or enriched foods with lipid profile in healthy adults were included. All outcomes were recorded as continuous variables, and the effect size was measured by analysis of the mean and standard deviation before and after the intervention for case and control groups. SUBJECTS: Healthy adult population.

resultsCLA supplementation was associated with a significant decrease in LDL cholesterol (mean difference = -0.218; 95% CI -0.358, -0.077; P = 0.002), a non-significant decrease in HDL cholesterol (mean difference = -0.051; 95% CI -0.188, 0.086; P = 0.468), a non-significant increase in total cholesterol (mean difference = 0.009; 95% CI -0.128, 0.146; P = 0.896) and a non-significant decrease in TAG (mean difference = -0.065; 95% CI -0.20, 0.07; P = 0.344). Foods enriched with CLA were associated with significantly decreased LDL cholesterol (mean difference = -0.231; 95% CI -0.438, -0.024; P = 0.028), non-significantly increased HDL-C (mean difference = 0.075; 95% CI -0.121, 0.270; P=0.455), non-significantly decreased total cholesterol (mean difference = -0.158; 95% CI -0.349, 0.042; P = 0.124) and non-significantly decreased TAG (mean difference = -0.078; 95% CI -0.274, 0.117; P = 0.433).

conclusionsAccording to our analysis, consumption of foods enriched with CLA or CLA supplements has favourable effects on LDL cholesterol levels.

Indexed as

DietDietary SupplementsCholesterolHumansLinoleic Acids, ConjugatedTriglyceridesCholesterolLinoleic Acids, ConjugatedTriglyceridesConjugated linoleic acidHDL cholesterolLDL cholesterolTAGTotal cholesterol

Identifiers

PMID25379623
PMCPMC10271550
OpenAlexW2172241038

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.