ArticleAsia Pacific allergy2014
Innate lymphoid cells and cytokines of the novel subtypes of helper T cells in asthma.
Article in Asia Pacific allergy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Role of IL-22 in persistent allergic airway diseases caused by house dust mite: a pilot study.BMC pulmonary medicine · 2021Article
- Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps.Allergy, asthma & immunology research · 2020Article
- An Update on Interleukin-9: From Its Cellular Source and Signal Transduction to Its Role in Immunopathogenesis.International journal of molecular sciences · 2019Review
- Anti-Interleukin-9 Antibody Increases the Effect of Allergen-Specific Immunotherapy in Murine Allergic Rhinitis.Allergy, asthma & immunology research · 2017Article
- From bench to bedside: Therapeutic potential of interleukin-9 in the treatment of asthma.Experimental and therapeutic medicine · 2017Article
- IL-17 producing innate lymphoid cells 3 (ILC3) but not Th17 cells might be the potential danger factor for preeclampsia and other pregnancy associated diseases.International journal of clinical and experimental pathology · 2015Article
- Innate lymphocyte cells in asthma phenotypes.Clinical and translational allergy · 2015Review
- In the memory of Professor Felicidad Cua-Lim.Asia Pacific allergy · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this study, the expression of interleukin-9 (IL-9), IL-17, IL-22, and IL-25 genes that might be the potential predisposing factors for asthma as well as count of innate lymphoid cells (ILCs) as another source of inflammatory cytokines have been evaluated.
objectiveThe aim of this study was to evaluate the expression of newly identified helper T cells signature cytokines and amount of ILCs.
methodsBlood and sputum samples from 23 patients with moderate to severe asthma and 23 healthy volunteers were collected. The types of allergens to which our patients were sensitive were defined using immunoblotting method. Gene expression of studied cytokines was evaluated using quantitative transcription-polymerase chain reaction and ILCs were counted by the flow cytometry method.
resultsIn this research, the gene expressions of IL-9, IL-17, IL-22, and IL-25 were significantly higher in asthmatics, especially in the severe form of the disease. This increase was even higher in serum samples compared with sputum samples. Counting ILCs revealed their increase in comparison with normal people.
conclusionWe showed the importance of IL-25, IL-22, IL-17, and IL-9 cytokines in patients with asthma as their expression levels are increased and these increase are correlated with the severity of the disease. We also showed that the increased amount of ILCs in asthmatics could confirm their potential role in the immunopathogenesis of asthma as another source of inflammatory cytokines.
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