ArticleJournal of traditional and complementary medicine2014
Wound-healing Activity of the Aqueous Leaf Extract and Fractions of Ficus exasperata (Moraceae) and its Safety Evaluation on Albino Rats.
Article in Journal of traditional and complementary medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Wound healing potential of methanolic extract of Wrightia tinctoria fresh leaf.Die Naturwissenschaften · 2026Article
- Accelerated wound healing through tannin-rich Jaft extract, concentration-dependent efficacy and mechanistic insights from Quercus brantii ointment formulations.Scientific reports · 2025Article
- Mechanistic Wound Healing ofInternational journal of molecular sciences · 2025Article
- Ethnomedical Knowledge of Plants Used in Nonconventional Medicine for Wound Healing in Lubumbashi, Haut-Katanga Province, DR Congo.TheScientificWorldJournal · 2024Article
- Evaluation of Wound Healing and Anti-Inflammatory Activity of Hydroalcoholic Leaf Extract ofClinical, cosmetic and investigational dermatology · 2022Article
- Wound Healing Activity of 80% Methanolic Crude Extract and Solvent Fractions of the Leaves ofJournal of experimental pharmacology · 2022Article
- Skin Wound-Healing Potential of Polysaccharides from Medicinal MushroomJournal of fungi (Basel, Switzerland) · 2021Article
- Gel formulations ofJournal of traditional and complementary medicine · 2021Article
- Acute Wound Healing Potential of Marine Worm,Evidence-based complementary and alternative medicine : eCAM · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ficus exasperata have been reported to have wide applications in the treatment of many human diseases. However, its traditional use in the treatment of wounds has not been validated by any scientific study. Also, its safety in the management of chronic disease conditions requires attention. We evaluated the wound-healing activity of the aqueous extract and fractions of F. exasperata, as well as its safety after subchronic oral administration. Similar percentage of wound contraction was observed with 5% w/w extract ointment application and administration of cicatrin powder (standard) on the 4(th) day, while better contraction than the standard was recorded with higher concentrations of the extract ointment. Of all the fractions tested, significant (P < 0.05) contraction was only noticed in chloroform fraction, though lower than that of the aqueous extract. The extract also showed concentration-dependent inhibition of all the tested microbial isolates. Extract administered up to 5000 mg/kg (single dose administration) did not cause any mortality after 24 h. Mortality was, however, recorded at 4000 mg/kg within the first 20 days of subchronic administration of the extract. Significant (P < 0.05) increases in alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and in particular, alkaline phosphatase (ALP) were observed at different doses and time periods. Pathological and histological changes were noticed in the liver and kidney on the 91(st) day of the study with 4000 mg/kg of the extract. Except for the significant (P < 0.05) reduction in WBC on the 91(st) day, no other significant (P < 0.05) changes were observed in other hematological parameters. The aqueous extract demonstrated better wound-healing activity than its fractions; however, the extract may not be safe at higher doses for subchronic oral administration, as may be the case in the management of chronic disease conditions.
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