ArticleNeuroImage. Clinical2014
48 echo T₂ myelin imaging of white matter in first-episode schizophrenia: evidence for aberrant myelination.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Transdiagnostic alterations of intrinsic brain activity in major psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Brain microstructure alterations in subjective cognitive decline: a multi-component T2 relaxometry study.Brain communications · 2025Article
- Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review.Journal of neurochemistry · 2024Review
- So You Want to Image Myelin Using MRI: Magnetic Susceptibility Source Separation for Myelin Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- Article
- Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults.Frontiers in aging neuroscience · 2023Article
- Myelin water fraction decrease in individuals with chronic mild traumatic brain injury and persistent symptoms.Heliyon · 2021Article
- Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders.Frontiers in psychiatry · 2021Review
- Constructing an Axonal-Specific Myelin Developmental Graph and its Application to Childhood Absence Epilepsy.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography.Schizophrenia bulletin · 2020Article
- The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter - A Multiparametric MRI Aging Study.Frontiers in neuroscience · 2020Article
- The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour.Nature communications · 2019Article
- Data fusion detects consistent relations between non-lesional white matter myelin, executive function, and clinical characteristics in multiple sclerosis.NeuroImage. Clinical · 2019Article
- Review
- Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter.Scientific reports · 2018Article
- Myelin water imaging to detect demyelination and remyelination and its validation in pathology.Brain pathology (Zurich, Switzerland) · 2018Review
- Advances in noninvasive myelin imaging.Developmental neurobiology · 2018Review
- Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia.Translational psychiatry · 2017Review
- Magnetic Resonance of Myelin Water: AnBrain plasticity (Amsterdam, Netherlands) · 2016Review
- Adult age differences in subcortical myelin content are consistent with protracted myelination and unrelated to diffusion tensor imaging indices.NeuroImage · 2016Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myelin water imaging provides a novel strategy to assess myelin integrity and corresponding clinical relationships in psychosis, of particular relevance in frontal white matter regions. In the current study, T2 myelin water imaging was used to assess the myelin water fraction (MWF) signal from frontal areas in a sample of 58 individuals experiencing first-episode psychosis (FEP) and 44 healthy volunteers. No differences in frontal MWF were observed between FEP subjects and healthy volunteers; however, differences in normal patterns of associations between frontal MWF and age, education and IQ were seen. Significant positive relationships between frontal MWF and age, North American Adult Reading Test (NAART) IQ, and years of completed education were observed in healthy volunteers. In contrast, only the relationship between frontal MWF and NAART IQ was significant after Bonferroni correction in the FEP group. Additionally, significant positive relationships between age and MWF in the anterior and posterior internal capsules, the genu, and the splenium were observed in healthy volunteers. In FEP subjects, only the relationship between age and MWF in the splenium was statistically significant. Frontal MWF was not associated with local white matter volume. Altered patterns of association between age, years of education, and MWF in FEP suggest that subtle disturbances in myelination may be present early in the course of psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.