Observational studyNeuroImage. Clinical2014
MRI correlates of disability progression in patients with CIS over 48 months.
Observational study in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis.Frontiers in immunology · 2019Trial
- A systematic literature review of the association between global brain atrophy and the Expanded Disability Status Scale score in people with multiple sclerosis.Therapeutic advances in neurological disorders · 2025Review
- Multisite MRI reproducibility of lateral ventricular volume using the NAIMS cooperative pilot dataset.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Predictive MRI Biomarkers in MS-A Critical Review.Medicina (Kaunas, Lithuania) · 2022Review
- Radiologically Isolated Syndrome: A Review for Neuroradiologists.AJNR. American journal of neuroradiology · 2020Review
- Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2020Article
- New and enlarging white matter lesions adjacent to the ventricle system and thalamic atrophy are independently associated with lateral ventricular enlargement in multiple sclerosis.Journal of neurology · 2020Article
- Peripheral blood lymphocytes immunophenotyping predicts disease activity in clinically isolated syndrome patients.BMC neurology · 2017Article
- Serum lipid profile changes predict neurodegeneration in interferon-β1a-treated multiple sclerosis patients.Journal of lipid research · 2017Article
- Structural Brain Network Characteristics Can Differentiate CIS from Early RRMS.Frontiers in neuroscience · 2016Article
- The effect of disease-modifying therapies on brain atrophy in patients with clinically isolated syndrome: a systematic review and meta-analysis.Therapeutic advances in neurological disorders · 2015Article
- Longitudinal Mixed-Effect Model Analysis of the Association between Global and Tissue-Specific Brain Atrophy and Lesion Accumulation in Patients with Clinically Isolated Syndrome.AJNR. American journal of neuroradiology · 2015Observational
- Quantifying brain tissue volume in multiple sclerosis with automated lesion segmentation and filling.NeuroImage. Clinical · 2015Article
- Brain atrophy and employment in multiple sclerosis patients: a 10-year follow-up study.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGray matter (GM) and white matter (WM) pathology has an important role in disease progression of multiple sclerosis (MS).
objectivesTo investigate the association between the development of GM and WM pathology and clinical disease progression in patients with clinically isolated syndrome (CIS).
methodsThis prospective, observational, 48-month follow-up study examined 210 CIS patients treated with 30 µg of intramuscular interferon beta-1a once a week. MRI and clinical assessments were performed at baseline, 6, 12, 24, 36 and 48 months. Associations between clinical worsening [24-weeks sustained disability progression (SDP) and occurrence of a second clinical attack] and longitudinal changes in lesion accumulation and brain atrophy progression were investigated by a mixed-effect model analysis after correction for multiple comparisons.
resultsSDP was observed in 32 (15.2%) CIS patients, while 146 (69.5%) were stable and 32 (15.2%) showed sustained disability improvement. 112 CIS patients (53.3%) developed clinically definite MS (CDMS). CIS patients who developed SDP showed increased lateral ventricle volume (p < .001), and decreased GM (p = .011) and cortical (p = .001) volumes compared to patients who remained stable or improved in disability. Converters to CDMS showed an increased rate of accumulation of number of new/enlarging T2 lesions (p < .001), decreased whole brain (p = .007) and increased lateral ventricle (p = .025) volumes.
conclusionsDevelopment of GM pathology and LVV enlargement are associated with SDP. Conversion to CDMS in patients with CIS over 48 months is dependent on the accumulation of new lesions, LVV enlargement and whole brain atrophy progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.