Evidence map›Paper›PMID 25379434›Full record

ArticleNeuroImage. Clinical2014

Aberrant spontaneous brain activity in chronic tinnitus patients revealed by resting-state functional MRI.

Yu-Chen Chen, Jian Zhang, Xiao-Wei Li, Wenqing Xia, Xu Feng, Bo Gao, Sheng-Hong Ju, Jian Wang, Richard Salvi, Gao-Jun Teng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  11. Tinnitus, sound intolerance, and mental health: the role of long-term occupational noise exposure.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu-Chen ChenDepartment of Radiology, Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Jian ZhangDepartment of Radiology, Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Xiao-Wei LiDepartment of Physiology, Southeast University, Nanjing, China.
Wenqing XiaMedical School, Southeast University, Nanjing, China.
Xu FengDepartment of Otolaryngology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Bo GaoDepartment of Radiology, Yantai Yuhuangding Hospital, Yantai, Shandong, China.
Sheng-Hong JuDepartment of Radiology, Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Jian WangDepartment of Physiology, Southeast University, Nanjing, China ; School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada.
Richard SalviCenter for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA.
Gao-Jun TengDepartment of Radiology, Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe neural mechanisms that give rise to the phantom sound of tinnitus are poorly understood. This study aims to investigate whether aberrant spontaneous brain activity exists in chronic tinnitus patients using resting-state functional magnetic resonance imaging (fMRI) technique. MATERIALS AND

methodsA total of 31 patients with chronic tinnitus patients and 32 healthy age-, sex-, and education-matched healthy controls were prospectively examined. Both groups had normal hearing thresholds. We calculated the amplitude of low-frequency fluctuations (ALFFs) of fMRI signals to measure spontaneous neuronal activity and detect the relationship between fMRI information and clinical data of tinnitus.

resultsCompared with healthy controls, we observed significant increased ALFF within several selected regions including the right middle temporal gyrus (MTG), right superior frontal gyrus (SFG), and right angular gyrus; decreased ALFF was detected in the left cuneus, right middle occipital gyrus and bilateral thalamus. Moreover, tinnitus distress correlated positively with increased ALFF in right MTG and right SFG; tinnitus duration correlated positively with higher ALFF values in right SFG.

conclusionsThe present study confirms that chronic tinnitus patients have aberrant ALFF in many brain regions, which is associated with specific clinical tinnitus characteristics. ALFF disturbance in specific brain regions might be used to identify the neuro-pathophysiological mechanisms in chronic tinnitus patients.

Indexed as

AdultBrainBrain MappingChronic DiseaseFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRestTinnitusYoung AdultALFFChronic tinnitusfMRI

Identifiers

PMID25379434
PMCPMC4215464

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.