Evidence map›Paper›PMID 25379431›Full record

Trial reportNeuroImage. Clinical2014

Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: a fNIRS study.

Masako Nagashima, Yukifumi Monden, Ippeita Dan, Haruka Dan, Daisuke Tsuzuki, Tsutomu Mizutani, Yasushi Kyutoku, Yuji Gunji, Daisuke Hirano, Takamichi Taniguchi and 4 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  12. Review
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  17. Clinical Applications of Functional Near-Infrared Spectroscopy in Children and Adolescents with Psychiatric Disorders.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2021
    Review
  18. Article
  19. Article
  20. Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Masako NagashimaDepartment of Pediatrics, Shimotsuke, Japan.
Yukifumi MondenDepartment of Pediatrics, Shimotsuke, Japan.
Ippeita DanDepartment of Neurosurgery, Shimotsuke, Japan ; Applied Cognitive Neuroscience Laboratory, Chuo University, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan.
Haruka DanDepartment of Neurosurgery, Shimotsuke, Japan.
Daisuke TsuzukiApplied Cognitive Neuroscience Laboratory, Chuo University, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan.
Tsutomu MizutaniDepartment of Pediatrics, Shimotsuke, Japan ; Functional Brain Science Laboratory, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Yasushi KyutokuApplied Cognitive Neuroscience Laboratory, Chuo University, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan.
Yuji GunjiDepartment of Pediatrics, Shimotsuke, Japan ; Department of Pediatrics, International University of Health and Welfare, 537-3 Iguchi, Nasushiobara, Tochigi 329-2763, Japan.
Daisuke HiranoInternational University of Health and Welfare, 2600-1 Kitakanemaru, Otawara, Tochigi, Japan.
Takamichi TaniguchiInternational University of Health and Welfare, 2600-1 Kitakanemaru, Otawara, Tochigi, Japan.
Hideo ShimoizumiRehabilitation Center, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara, Tochigi 324-8501, Japan.
Mariko Y MomoiDepartment of Pediatrics, Shimotsuke, Japan ; International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara, Tochigi, Japan.
Eiju WatanabeDepartment of Neurosurgery, Shimotsuke, Japan.
Takanori YamagataDepartment of Pediatrics, Shimotsuke, Japan.
International University of Health and Welfare · JPChuo University · JPJichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The object of the current study is to explore the neural substrate for effects of atomoxetine (ATX) on inhibitory control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS). We monitored the oxy-hemoglobin signal changes of sixteen ADHD children (6-14 years old) performing a go/no-go task before and 1.5 h after ATX or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Sixteen age- and gender-matched normal controls without ATX administration were also monitored. In the control subjects, the go/no-go task recruited the right inferior and middle prefrontal gyri (IFG/MFG), and this activation was absent in pre-medicated ADHD children. The reduction of right IFG/MFG activation was acutely normalized after ATX administration but not placebo administration in ADHD children. These results are reminiscent of the neuropharmacological effects of methylphenidate to up-regulate reduced right IFG/MFG function in ADHD children during inhibitory tasks. As with methylphenidate, activation in the IFG/MFG could serve as an objective neuro-functional biomarker to indicate the effects of ATX on inhibitory control in ADHD children. This promising technique will enhance early clinical diagnosis and treatment of ADHD in children, especially in those with a hyperactivity/impulsivity phenotype.

Indexed as

AdolescentAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityBrainChildCross-Over StudiesDouble-Blind MethodExecutive FunctionFemaleHumansMalePropylaminesSpectroscopy, Near-InfraredAtomoxetine HydrochloridePropylaminesCortical hemodynamicsDevelopmental disorderDorsolateral prefrontal cortexOptical topographyStop signal task

Identifiers

PMID25379431
PMCPMC4215398
OpenAlexW2029932742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.