ArticleNeuroImage. Clinical2014
The effects of deefferentation without deafferentation on functional connectivity in patients with facial palsy.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Exploratory Study of the Brain Response in Facial Synkinesis after Bell Palsy with Systematic Review and Meta-analysis of the Literature.AJNR. American journal of neuroradiology · 2022Pooled it
- The "Mirror Effect Plus Protocol" for acute Bell's palsy: A randomized controlled trial with 1-year follow-up.Clinical rehabilitation · 2022Trial
- Cause or effect: Altered brain and network activity in cervical dystonia is partially normalized by botulinum toxin treatment.NeuroImage. Clinical · 2019Trial
- Cerebral plasticity after hypoglosso-facial anastomosis in facial palsy: a magnetoencephalography study.Neuroimage. Reports · 2025Article
- Alterations in neuroplasticity and functional connectivity of striatal subregions in Bell's palsy patients after acupuncture.Frontiers in neurology · 2025Article
- Investigation of functional connectivity in Bell's palsy using functional magnetic resonance imaging: prospective cross-sectional study.Quantitative imaging in medicine and surgery · 2023Article
- Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system.Frontiers in cellular neuroscience · 2023Review
- Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry.Frontiers in neuroscience · 2022Article
- Alteration of spatial patterns at the network-level in facial synkinesis: an independent component and connectome analysis.Annals of translational medicine · 2021Article
- Effect of an Intensified Combined Electromyography and Visual Feedback Training on Facial Grading in Patients With Post-paralytic Facial Synkinesis.Frontiers in rehabilitation sciences · 2021Article
- Selective Denervation of the Facial Dermato-Muscular Complex in the Rat: Experimental Model and Anatomical Basis.Frontiers in neuroanatomy · 2021Article
- Shaping the Sensory-Motor Network by Short-Term Unresolvable Sensory-Motor Mismatch.Frontiers in neurology · 2021Article
- Altered brain language network in idiopathic peripheral facial paralysis patients with dysarthria.Annals of translational medicine · 2020Article
- Abnormal Emotional Processing and Emotional Experience in Patients with Peripheral Facial Nerve Paralysis: An MEG Study.Brain sciences · 2020Article
- Differences in functional brain alterations driven by right or left facial nerve efferent dysfunction: Evidence from early Bell's palsy.Quantitative imaging in medicine and surgery · 2019Article
- Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell's Palsy.Frontiers in aging neuroscience · 2019Article
- Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement.Neural plasticity · 2019Article
- Reorganization of sensory input at brainstem in hemifacial spasm and postparalytic facial syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell's Palsy: Do They Have Differences?Frontiers in neuroscience · 2018Article
- Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients.NeuroImage. Clinical · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral plasticity includes the adaptation of anatomical and functional connections between parts of the involved brain network. However, little is known about the network dynamics of these connectivity changes. This study investigates the impact of a pure deefferentation, without deafferentation or brain damage, on the functional connectivity of the brain. To investigate this issue, functional MRI was performed on 31 patients in the acute state of Bell's palsy (idiopathic peripheral facial nerve palsy). All of the patients performed a motor paradigm to identify seed regions involved in motor control. The functional connectivity of the resting state within this network of brain regions was compared to a healthy control group. We found decreased connectivity in patients, mainly in areas responsible for sensorimotor integration and supervision (SII, insula, thalamus and cerebellum). However, we did not find decreased connectivity in areas of the primary or secondary motor cortex. The decreased connectivity for the SII and the insula significantly correlated to the severity of the facial palsy. Our results indicate that a pure deefferentation leads the brain to adapt to the current compromised state during rest. The motor system did not make a major attempt to solve the sensorimotor discrepancy by modulating the motor program.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.