ArticleOsong public health and research perspectives2014
High Prevalence of Class 1 to 3 Integrons Among Multidrug-Resistant Diarrheagenic Escherichia coli in Southwest of Iran.
Article in Osong public health and research perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed.
- A One Health Perspective onMicroorganisms · 2026Review
- High prevalence of class 1 integron, biofilm formation, and antimicrobial resistance profiles of Escherichia coli isolated from cattle, water, and soil in Bangladesh.BMC microbiology · 2026Article
- Genes and physiological strategies in bacterial antibiotic resistance.Frontiers in microbiology · 2026Review
- Genomic characterization of a mobile-element-associated resistance island in trimethoprim-sulfamethoxazole-resistantFrontiers in cellular and infection microbiology · 2026Article
- Occurrence of Virulence and Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2025Article
- Detection of Integrons inInternational journal of microbiology · 2025Article
- Integrons in the Age of Antibiotic Resistance: Evolution, Mechanisms, and Environmental Implications: A Review.Microorganisms · 2024Review
- Agricultural Soil as a Reservoir ofMicroorganisms · 2024Article
- Tracing the Evolutionary Pathways of Serogroup O78 Avian PathogenicAntibiotics (Basel, Switzerland) · 2023Article
- Brucella abortus antigen omp25 vaccines: Development and targeting based on Lactococcus lactis.Veterinary medicine and science · 2023Article
- Extended-Spectrum β-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2023Article
- Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors.International journal of molecular sciences · 2023Review
- Integrons in the development of antimicrobial resistance: critical review and perspectives.Frontiers in microbiology · 2023Review
- Article
- Evaluation of Retail Meat as a Source of ESBLAntibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial resistance and genetic diversity ofOne health (Amsterdam, Netherlands) · 2022Article
- Antibiotic Susceptibility Profiles and Resistance Mechanisms to β-Lactams and Polymyxins ofMicroorganisms · 2022Article
- Prevalence and characterisation of antimicrobial resistance genes and class 1 and 2 integrons in multiresistant Escherichia coli isolated from poultry production.Scientific reports · 2022Article
- Molecular Detection of Integrons, Colistin andMicroorganisms · 2022Article
- Prevalence and Characterization of ESBL/AmpC ProducingAntibiotics (Basel, Switzerland) · 2021Article
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5 authors.
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Abstract
objectivesHorizontal transfer of integrons is one of the important factors that can contribute to the occurrence of multidrug-resistant (MDR) bacteria. This study aimed to determine the prevalence of integrons among MDR Escherichia coli strains isolated from stool specimens and investigate the associations between the existence of integrons and MDR properties in the southwest of Iran.
methodsThere were 164 E. coli strains isolated from January 2012 to June 2012. Fecal specimens identified as E. coli by the conventional methods. Subsequently the antibiotic resistance was assessed using Clinical and Laboratory Standard Institute criteria. The presence of class 1-3 integrons and embedded gene cassettes was verified using specific primers by multiplex polymerase chain reaction assay.
resultsAmong a total of 164 studied samples, 69 (42.07%) isolates were multidrug resistant. Class 1 and class 2 integrons were present in 78.26% and 76.81% MDR isolates, respectively. For the first time in Iran, class 3 integron was observed in 26.09% MDR isolates. Significant correlations were identified between: class 1 integron and resistance to amikacin, gentamicin, chloramphenicol, ampicillin, tetracycline, nalidixic acid, and co-trimoxazole; class 2 integron and resistance to aminoglycosides, co-trimoxazole, cefalexin, ampicillin, and chloramphenicol; and class 3 integron and resistance to gentamicin, kanamycin, and streptomycin.
conclusionOur results indicate that integrons are common among MDR isolates and they can be used as a marker for the identification of MDR isolates. Therefore, due to the possibility of a widespread outbreak of MDR isolates, molecular surveillance and sequencing of the integrons in other parts of the country is recommended.
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