Evidence map›Paper›PMID 25379295›Full record

ArticleCase reports in dentistry2014

Severe periodontal disease associated with long-term treatment with intravenous immunoglobulin.

Jôice Dias Corrêa, Amanda Leal Rocha, Lidiane Cristina Machado Costa, Denise Travassos, Wagner Henriques Castro, Gustavo Pompermaier Garlet, Rodrigo Santiago Gomez, Antônio Lúcio Teixeira, Tarcília Aparecida Silva

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In one paragraph

Article in Case reports in dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jôice Dias CorrêaDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Amanda Leal RochaSpecial Service for Diagnosis and Treatment in Dentistry (SEDTO), Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, Brazil.
Lidiane Cristina Machado CostaDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Denise TravassosSpecial Service for Diagnosis and Treatment in Dentistry (SEDTO), Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, Brazil ; Department of Community and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Wagner Henriques CastroDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil ; Special Service for Diagnosis and Treatment in Dentistry (SEDTO), Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, Brazil.
Gustavo Pompermaier GarletDepartment of Biological Sciences, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil.
Rodrigo Santiago GomezNeurology Service, Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, Brazil.
Antônio Lúcio TeixeiraNeurology Service, Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, Brazil.
Tarcília Aparecida SilvaDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil ; Special Service for Diagnosis and Treatment in Dentistry (SEDTO), Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous immunoglobulin (IVIG) is used in the treatment of neuropathy. This case report presents, for the first time, a patient with severe periodontal destruction after chronic therapy with IVIG. The patient reported having extracted his maxillary anterior teeth himself due to high mobility. Clinical examination and radiographic images show a generalized and severe periodontitis. No significant alterations in genetic or microbiological features were observed. The present case suggests that periodontal disease aggravation could be considered a new adverse effect of IVIG therapy. Postulated mechanisms are immune complexes formation, complement activation, and a direct effect in osteoclasts. In conclusion, it is important that patients that will receive IVIG treatment underwent dental evaluation.

Identifiers

PMID25379295
PMCPMC4213401

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