ReviewBehavioral sciences (Basel, Switzerland)2013
Memory deficits in schizophrenia: a selective review of functional magnetic resonance imaging (FMRI) studies.
Review in Behavioral sciences (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Aberrant cortical-subcortical-cerebellar connectivity in resting-state fMRI as an imaging marker of schizophrenia and psychosis: a systematic review of data-driven whole-brain functional connectivity analyses.Frontiers in neuroimaging · 2025Pooled it
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies.Neuropsychopharmacology reports · 2018Pooled it
- Effective connectivity during episodic memory retrieval in schizophrenia participants before and after antipsychotic medication.Human brain mapping · 2015Trial
- Adjunct Bifrontal Transcranial Direct Current Stimulation in Improving Cognitive Insight and Working Memory Deficits in Schizophrenia: A Single-blind, Randomised Sham-controlled Trial.Annals of neurosciences · 2025Article
- Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks.Diagnostics (Basel, Switzerland) · 2025Article
- Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings.BMC medicine · 2025Article
- Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis.Brain sciences · 2024Article
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects.Frontiers in neurology · 2024Article
- Genetic and Epigenetic Regulation inInternational journal of molecular sciences · 2023Article
- Excitatory and inhibitory imbalances in the trisynaptic pathway in the hippocampus in schizophrenia: a postmortem ultrastructural study.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- The effect of multisensory semantic congruency on unisensory object recognition in schizophrenia.Frontiers in psychiatry · 2023Article
- Exploring the link between cognitive deficit, self-esteem, alexithymia, and depressive symptom of schizophrenia.Brain and behavior · 2022Article
- Neural basis of the visual working memory deficit in schizophrenia: Merging evidence from fMRI and EEG.Schizophrenia research · 2021Article
- Reduced Hippocampal Volume and Its Relationship With Verbal Memory and Negative Symptoms in Treatment-Naive First-Episode Adolescent-Onset Schizophrenia.Schizophrenia bulletin · 2021Article
- Neural Signatures of Memory Encoding in Schizophrenia Are Modulated by Antipsychotic Treatment.Neuropsychobiology · 2021Article
- Prefrontal cortical alterations of glutamate and GABA neurotransmission in schizophrenia: Insights for rational biomarker development.Biomarkers in neuropsychiatry · 2020Article
- What a Clinician Should Know About the Neurobiology of Schizophrenia: A Historical Perspective to Current Understanding.Focus (American Psychiatric Publishing) · 2020Article
- Selective Review of Neuroimaging Findings in Youth at Clinical High Risk for Psychosis: On the Path to Biomarkers for Conversion.Frontiers in psychiatry · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Schizophrenia is a complex chronic mental illness that is characterized by positive, negative and cognitive symptoms. Cognitive deficits are most predictive of long-term outcomes, with abnormalities in memory being the most robust finding. The advent of functional magnetic resonance imaging (fMRI) has allowed exploring neural correlates of memory deficits in vivo. In this article, we will give a selective review of fMRI studies probing brain regions and functional networks that are thought to be related to abnormal memory performance in two memory systems prominently affected in schizophrenia; working memory and episodic memory. We revisit the classic "hypofrontality" hypothesis of working memory deficits and explore evidence for frontotemporal dysconnectivity underlying episodic memory abnormalities. We conclude that fMRI studies of memory deficits in schizophrenia are far from universal. However, the current literature does suggest that alterations are not isolated to a few brain regions, but are characterized by abnormalities within large-scale brain networks.
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Registered trials
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