ArticleBehavioral sciences (Basel, Switzerland)2012
Physiological consequences of repeated exposures to conditioned fear.
Article in Behavioral sciences (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Hypoglossal Nerve Transection Induces Anxiety- and Depression-like Behaviors with HPA Axis Dysregulation in Rats.Bioengineering (Basel, Switzerland) · 2026Article
- Fear in general populations: A cross-sectional study on perceived fear of common diseases, COVID-19, life events, and environmental threats in 30 countries.Journal of global health · 2024Article
- Influences on Infrared Thermography of the Canine Eye in Relation to the Stress and Arousal of Racing Greyhounds.Animals : an open access journal from MDPI · 2021Article
- Dietary prebiotics alter novel microbial dependent fecal metabolites that improve sleep.Scientific reports · 2020Article
- Comment on "Multiple repressive mechanisms in the hippocampus during memory formation".Science (New York, N.Y.) · 2016Article
- Wheel running improves REM sleep and attenuates stress-induced flattening of diurnal rhythms in F344 rats.Stress (Amsterdam, Netherlands) · 2016Article
- Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity.Frontiers in behavioral neuroscience · 2016Article
- Repeated exposure to conditioned fear stress increases anxiety and delays sleep recovery following exposure to an acute traumatic stressor.Frontiers in psychiatry · 2014Article
- Effects of stressor controllability on diurnal physiological rhythms.Physiology & behavior · 2013Article
- Interleukin-1 beta: a potential link between stress and the development of visceral obesity.BMC physiology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of the stress response evokes a cascade of physiological reactions that may be detrimental when repeated or chronic, and when triggered after exposure to psychological/emotional stressors. Investigation of the physiological mechanisms responsible for the health damaging effects requires animal paradigms that repeatedly evoke a response to psychological/emotional stressors. To this end, adult male Sprague Dawley rats were repeatedly exposed (2X per day for 20 days) to a context that they were conditioned to fear (conditioned fear test, CFT). Repeated exposure to CFT produced body weight loss, adrenal hypertrophy, thymic involution, and basal corticosterone elevation. In vivo biotelemetry measures revealed that CFT evokes sympathetic nervous system driven increases in heart rate (HR), mean arterial pressure (MAP), and core body temperature. Extinction of behavioral (freezing) and physiological responses to CFT was prevented using minimal reinstatement footshock. MAP responses to the CFT did not diminish across 20 days of exposure. In contrast, HR and cardiac contractility responses declined by day 15, suggesting a shift toward vascular-dominated MAP (a pre-clinical marker of CV dysfunction). Flattened diurnal rhythms, common to stress-related mood/anxiety disorders, were found for most physiological measures. Thus, repeated CFT produces adaptations indicative of the health damaging effects of psychological/emotional stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.