ArticleBiomicrofluidics2014
Deformation of red blood cells using acoustic radiation forces.
Article in Biomicrofluidics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Recent advances in microscale techniques for red blood cells manipulation.Biomicrofluidics · 2025Review
- Spatial regulation of hydrogel polymerization reaction using ultrasound-driven streaming vortex.Ultrasonics sonochemistry · 2024Article
- Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation.Nature communications · 2024Article
- An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood.Microsystems & nanoengineering · 2024Article
- Numerical Model Validation of the Blood Flow through a Microchannel Hyperbolic Contraction.Micromachines · 2023Article
- Holographic Focused Ultrasound Hyperthermia System for Uniform Simultaneous Thermal Exposure of Multiple Tumor Spheroids.Cancers · 2023Article
- Methods to mechanically perturb and characterize GUV-based minimal cell models.Computational and structural biotechnology journal · 2023Review
- Acousto-holographic reconstruction of whole-cell stiffness maps.Nature communications · 2022Article
- Persistent red blood cells retain their ability to move in microcapillaries under high levels of oxidative stress.Communications biology · 2022Article
- Manipulation and Mechanical Deformation of Leukemia Cells by High-Frequency Ultrasound Single Beam.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Acoustofluidic interferometric device for rapid single-cell physical phenotyping.European biophysics journal : EBJ · 2022Article
- Ultrasonic Particle Manipulation in Glass Capillaries: A Concise Review.Micromachines · 2021Review
- Bandpass sorting of heterogeneous cells using a single surface acoustic wave transducer pair.Biomicrofluidics · 2021Article
- Microparticle Acoustophoresis in Aluminum-Based Acoustofluidic Devices with PDMS Covers.Micromachines · 2020Article
- A Quantitative Study of the Secondary Acoustic Radiation Force on Biological Cells during Acoustophoresis.Micromachines · 2020Article
- On-chip surface acoustic wave and micropipette aspiration techniques to assess cell elastic properties.Biomicrofluidics · 2020Article
- Modulation of acoustomechanical instability and bifurcation behavior of soft materials.Scientific reports · 2018Article
- Acousto-thermo-mechanical deformation of hydrogels coupled with chemical diffusion.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- A rapid and meshless analytical model of acoustofluidic pressure fields for waveguide design.Biomicrofluidics · 2018Article
- Theoretically proposed optimal frequency for ultrasound induced cartilage restoration.Theoretical biology & medical modelling · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acoustic radiation forces have been used to manipulate cells and bacteria in a number of recent microfluidic applications. The net force on a cell has been subject to careful investigation over a number of decades. We demonstrate that the radiation forces also act to deformcells. An ultrasonic standing wave field is created in a 0.1 mm glass capillary at a frequency of 7.9 MHz. Using osmotically swollen red-blood cells, we show observable deformations up to an aspect ratio of 1.35, comparable to deformations created by optical tweezing. In contrast to optical technologies, ultrasonic devices are potentially capable of deforming thousands of cells simultaneously. We create a finite element model that includes both the acoustic environment of the cell, and a model of the cell membrane subject to forces resulting from the non-linear aspects of the acoustic field. The model is found to give reasonable agreement with the experimental results, and shows that the deformation is the result of variation in an acoustic force that is directed outwards at all points on the cell membrane. We foresee applications in diagnostic devices, and in the possibility of mechanically stimulating cells to promote differentiation and physiological effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.