ArticleFrontiers in endocrinology2014
A novel model for development, organization, and function of gonadotropes in fish pituitary.
Article in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 71 citations in OpenAlex.
- Differential hypothalamic regulation of FSH and LH secretion from the fish pituitary by GnRH and CCK.Reproduction (Cambridge, England) · 2025Article
- Hormonal dynamics reveal a stimulatory role for secretoneurin in zebrafish ovulation.PNAS nexus · 2025Article
- The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion.eLife · 2024Article
- GnRH-Gonadotropes Interactions Revealed by Pituitary Single-cell Transcriptomics in Zebrafish.Endocrinology · 2024Article
- Characterization of a novel fast-growing zebrafish: a new approach to growth hormone transgenesis.Frontiers in endocrinology · 2024Article
- Characterization of the somatostatin system in tilapia: implications for growth and reproduction.Frontiers in endocrinology · 2024Article
- Gonadotropins and Sex Steroid Hormones in Captive-Reared Small Yellow Croaker (International journal of molecular sciences · 2023Article
- Sexually Dimorphic Regulation of Gonadotrope Cell Hyperplasia in Medaka Pituitary via Mitosis and Transdifferentiation.Endocrinology · 2023Article
- Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon:Frontiers in endocrinology · 2022Article
- Transcriptomes of testis and pituitary from male Nile tilapia (O. niloticus L.) in the context of social status.PloS one · 2022Article
- Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary.International journal of molecular sciences · 2021Article
- Synaptic communication mediates the assembly of a self-organizing circuit that controls reproduction.Science advances · 2021Article
- 3D Atlas of the Pituitary Gland of the Model Fish Medaka (Frontiers in endocrinology · 2021Article
- Long extensions with varicosity-like structures in gonadotrope Lh cells facilitate clustering in medaka pituitary culture.PloS one · 2021Article
- Plasticity in medaka gonadotropes via cell proliferation and phenotypic conversion.The Journal of endocrinology · 2020Article
- Functional Pituitary Networks in Vertebrates.Frontiers in endocrinology · 2020Review
- Direct and Indirect Effects of Sex Steroids on Gonadotrope Cell Plasticity in the Teleost Fish Pituitary.Frontiers in endocrinology · 2020Review
- Characterization of gonadotropic cells during continuous and seasonal spermatogenesis of two freshwater fish species: a histochemical and immunohistochemical study.Fish physiology and biochemistry · 2017Article
- Anatomical and functional gonadotrope networks in the teleost pituitary.Scientific reports · 2016Article
- Zebrafish: A Versatile Animal Model for Fertility Research.BioMed research international · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are key regulators of the reproductive axis in vertebrates. Despite the high popularity of zebrafish as a model organism for studying reproductive functions, to date no transgenic zebrafish with labeled gonadotropes have been introduced. Using gonadotropin regulatory elements from tilapia, we generated two transgenic zebrafish lines with labeled gonadotropes. The tilapia and zebrafish regulatory sequences were highly divergent but several conserved elements allowed the tilapia promoters to correctly drive the transgenes in zebrafish pituitaries. FSH cells reacted to stimulation with gonadotropin releasing hormone by proliferating and showing increased transgene fluorescence, whereas estrogen exposure caused a decrease in cell number and transgene fluorescence. Transgene fluorescence reflected the expression pattern of the endogenous fshb gene. Ontogenetic expression of the transgenes followed typical patterns, with FSH cells appearing early in development, and LH cells appearing later and increasing dramatically in number with the onset of puberty. Our transgenic lines provide a powerful tool for investigating the development, anatomy, and function of the reproductive axis in lower vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.