ArticleJournal of ginseng research2014
Ginsenoside-Rp1-induced apolipoprotein A-1 expression in the LoVo human colon cancer cell line.
Article in Journal of ginseng research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
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- Plant-derived saponins and their prospective for cosmetic and personal care products.Botanical studies · 2024Review
- Adjuvant effects of Chinese medicinal tonics on gastric, liver, and colorectal cancers-OMICs-based contributions to understanding their mechanism of action.Frontiers in pharmacology · 2022Review
- Apolipoproteins: New players in cancers.Frontiers in pharmacology · 2022Review
- Efficacy of Ninjin'yoeito in treating severe coronavirus disease 2019 in patients in an intensive care unit.Neuropeptides · 2021Article
- AKT-targeted anti-inflammatory activity ofJournal of ginseng research · 2018Article
- Functional role of ginseng-derived compounds in cancer.Journal of ginseng research · 2018Review
- Pyrrole-Derivative of Chalcone, (Biomolecules & therapeutics · 2016Article
- Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells.Journal of ginseng research · 2016Article
- Molecular association of CD98, CD29, and CD147 critically mediates monocytic U937 cell adhesion.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Anti-Proliferative and Pro-Apoptotic Activities of 4-Methyl-2,6-bis(1-phenylethyl)phenol in Cancer Cells.Biomolecules & therapeutics · 2016Article
- Anticancer effect of joboksansam, Korean wild ginseng germinated from bird feces.Journal of ginseng research · 2016Article
- Syk and IRAK1 Contribute to Immunopharmacological Activities of Anthraquinone-2-carboxlic Acid.Molecules (Basel, Switzerland) · 2016Article
- Diagnostic and prognostic significance of serum apolipoprotein C-I in triple-negative breast cancer based on mass spectrometry.Cancer biology & therapy · 2016Article
- 4-(Tert-butyl)-2,6-bis(1-phenylethyl)phenol induces pro-apoptotic activity.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- 1-(2,3-Dibenzimidazol-2-ylpropyl)-2-methoxybenzene Is a Syk Inhibitor with Anti-Inflammatory Properties.Molecules (Basel, Switzerland) · 2016Article
- Diagnostic and prognostic role of serum protein peak at 6449 m/z in gastric adenocarcinoma based on mass spectrometry.British journal of cancer · 2016Article
- (E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-κB.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk.Biomolecules & therapeutics · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGinsenoside Rp1 (G-Rp1) is a novel ginsenoside derived from ginsenoside Rk1. This compound was reported to have anticancer, anti-platelet, and anti-inflammatory activities. In this study, we examined the molecular target of the antiproliferative and proapoptotic activities of G-Rp1.
methodsTo examine the effects of G-Rp1, cell proliferation assays, propidium iodine staining, proteomic analysis by two-dimensional gel electrophoresis, immunoblotting analysis, and a knockdown strategy were used.
resultsG-Rp1 dose-dependently suppressed the proliferation of colorectal cancer LoVo cells and increased their apoptosis. G-Rp1 markedly upregulated the protein level of apolipoprotein (Apo)-A1 in LoVo, SNU-407, DLD-1, SNU-638, AGS, KPL-4, and SK-BR-3 cells. The knockdown of Apo-A1 by its small-interfering RNA increased the levels of cleaved poly(ADP-ribose) polymerase and p53 and diminished the proliferation of LoVo cells.
conclusionThese results suggest that G-Rp1 may act as an anticancer agent by strongly inhibiting cell proliferation and enhancing apoptosis through upregulation of Apo-A1.
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