Evidence map›Paper›PMID 25378921›Full record

ReviewInternational journal of chronic obstructive pulmonary disease2014

Oxidative stress and free radicals in COPD--implications and relevance for treatment.

Wolfgang Domej, Karl Oettl, Wilfried Renner

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of chronic obstructive pulmonary disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07376161 (The Effect of Pulmonary Rehabilitation on Inflammation and Oxidative Stress in COPD), which is not on this map. Cited by 143 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 6 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07376161 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

The Effect of Pulmonary Rehabilitation on Inflammation and Oxidative Stress in COPD

Typeobservational_patient_registrySponsorEsra YazarRan2026 to 2026Enrolled27ConditionsInflamation, COPD, Oxidative Stress, Pulmonary RehabilitationArmsPulmonary Rehabilitation
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 6 syntheses or guidelines pooled it, 309 citations in OpenAlex.

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  18. The therapeutic potential ofFrontiers in microbiology · 2026
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wolfgang DomejDivision of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Karl OettlInstitute of Physiological Chemistry, Medical University of Graz, Graz, Austria.
Wilfried RennerClinical Institute of Medical and Chemical Diagnostics, Medical University of Graz, Graz, Austria.
Medical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress occurs when free radicals and other reactive species overwhelm the availability of antioxidants. Reactive oxygen species (ROS), reactive nitrogen species, and their counterpart antioxidant agents are essential for physiological signaling and host defense, as well as for the evolution and persistence of inflammation. When their normal steady state is disturbed, imbalances between oxidants and antioxidants may provoke pathological reactions causing a range of nonrespiratory and respiratory diseases, particularly chronic obstructive pulmonary disease (COPD). In the respiratory system, ROS may be either exogenous from more or less inhalative gaseous or particulate agents such as air pollutants, cigarette smoke, ambient high-altitude hypoxia, and some occupational dusts, or endogenously generated in the context of defense mechanisms against such infectious pathogens as bacteria, viruses, or fungi. ROS may also damage body tissues depending on the amount and duration of exposure and may further act as triggers for enzymatically generated ROS released from respiratory, immune, and inflammatory cells. This paper focuses on the general relevance of free radicals for the development and progression of both COPD and pulmonary emphysema as well as novel perspectives on therapeutic options. Unfortunately, current treatment options do not suffice to prevent chronic airway inflammation and are not yet able to substantially alter the course of COPD. Effective therapeutic antioxidant measures are urgently needed to control and mitigate local as well as systemic oxygen bursts in COPD and other respiratory diseases. In addition to current therapeutic prospects and aspects of genomic medicine, trending research topics in COPD are presented.

Indexed as

Oxidative StressAnimalsAntioxidantsBiomarkersDisease ProgressionGenetic Predisposition to DiseaseHumansLungPulmonary Disease, Chronic ObstructiveReactive Nitrogen SpeciesReactive Oxygen SpeciesRisk FactorsSmokingAntioxidantsBiomarkersReactive Nitrogen SpeciesReactive Oxygen Speciesantioxidantschronic obstructive pulmonary diseasereactive nitrogen speciesreactive oxygen species

Identifiers

PMID25378921
PMCPMC4207545
OpenAlexW2026488076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.