Evidence map›Paper›PMID 25378808›Full record

ArticleJournal of toxicologic pathology2014

Effects of Repeated Intravenous Administration of Dextrans,Water-soluble Macromolecules, in Rats.

Ikue Kitazawa, Shino Ito, Yusuke Kagawa, Miki Suehiro-Narita, Naoto Hashizume, Yuka Minamisawa, Aisuke Nii, Akio Kawakami, Shinichi Nakajima

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of toxicologic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Ikue KitazawaCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Shino ItoCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Yusuke KagawaCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Miki Suehiro-NaritaCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Naoto HashizumeCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Yuka MinamisawaCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Aisuke NiiCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Akio KawakamiCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Shinichi NakajimaCentral Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Seikagaku Corporation (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the influence of repeated intravenous administration of dextrans (DEXs) to rats. Seven-week-old Sprague Dawley rats (6 males/group) were given intravenously 10% saline solutions of dextrans (DEXs), 40 kDa or 200-300 kDa, at a dose level of 5 mL/kg/day for 28 days and they were examined histopathologically. Another group (3 males/group) was administered saline in a similar manner and served as the control. Histopathological changes indicating accumulation of DEXs in the mononuclear phagocyte system (MPS) and the liver were noted in the treated groups. The incidence and severity of the findings were molecular weight-dependent, except for the lungs. These results are considered useful in interpreting data from preclinical studies, in which DEXs or their derivatives are administered as test or control substances.

Indexed as

intravenous administrationmacromolecular substancesmononuclear phagocyte system

Identifiers

PMID25378808
PMCPMC4217235
OpenAlexW2028910489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.