SynthesisJournal of lipid research2015
Genetic loci associated with circulating levels of very long-chain saturated fatty acids.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of lipid research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
2.3field-weighted citation impact, top 13% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Use of Mendelian Randomization to Unveil Metabolic Markers inJournal of Korean medical science · 2026Pooled it
- Pooled it
- Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta-Analysis in Up to 16 126 Participants.Journal of the American Heart Association · 2020Pooled it
- Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.PloS one · 2018Pooled it
- Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.European journal of cancer (Oxford, England : 1990) · 2017Pooled it
- Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians.European journal of nutrition · 2017Pooled it
- Application of lipidomics strategy to explore aging-related biomarkers and potential anti-aging mechanisms of ginseng.Biogerontology · 2021Trial
- Plasma Ceramides and Sphingomyelins in Relation to Heart Failure Risk.Circulation. Heart failure · 2019Trial
- Population-based genome-wide association study of plasma complex lipid species.Nature communications · 2026Article
- [The Relationship Between Serum Very Long-chain Saturated Fatty Acids and Chronic Kidney Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Application of Mendelian randomization to explore metabolic pathways in colorectal cancer.Annals of medicine and surgery (2012) · 2025Article
- GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.HGG advances · 2025Article
- Serum lipidomic analysis identifies potential therapeutic targets for neurodegeneration.Frontiers in human neuroscience · 2025Article
- SPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis.Cell reports · 2024Article
- Genome-wide association studies and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating polyunsaturated, monounsaturated, and saturated fatty acids.medRxiv : the preprint server for health sciences · 2024Article
- Ceramides as Biomarkers of Cardiovascular Diseases and Heart Failure.Current heart failure reports · 2024Review
- A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort.The Journal of nutrition · 2024Article
- Article
- Sequence Variant Analysis of theInternational journal of molecular sciences · 2023Article
- Design and quality control of large-scale two-sample Mendelian randomization studies.International journal of epidemiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 15 institutions in 4 countries.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.
Irena B KingDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM.
Edmond K KabagambeDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Jason H Y WuThe George Institute for Global Health, University of Sydney, Sydney, Australia.
Barbara McKnightDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA.
Ani ManichaikulCenter for Public Health Genomics University of Virginia, Charlottesville, VA Department of Public Health Sciences, Division of Biostatistics, University of Virginia, Charlottesville, VA.
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN.
Qi SunChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Departments of Nutrition Harvard School of Public Health, Boston, MA.
Daniel I ChasmanDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Millennia FoyInstitute of Molecular Medicine University of Texas Health Sciences Center-Houston, Houston, TX.
Lu WangDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jingwen ZhuKey Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
David S SiscovickCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA Departments of Epidemiology University of Washington, Seattle, WA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Donna K ArnettDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA Departments of Epidemiology University of Washington, Seattle, WA Health Services, University of Washington, Seattle, WA Group Health Research Institute, Group Health Cooperative, Seattle, WA.
Luc DjousseDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Boston Veterans Healthcare System, Boston, MA.
Yii-Der I ChenMedical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Lu-Chen WengDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Hongyu WuDepartments of Nutrition Harvard School of Public Health, Boston, MA.
Majken K JensenDepartments of Nutrition Harvard School of Public Health, Boston, MA.
Audrey Y ChuDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Stephen S RichCenter for Public Health Genomics University of Virginia, Charlottesville, VA.
Dariush MozaffarianChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Departments of Nutrition Harvard School of Public Health, Boston, MA Epidemiology, Harvard School of Public Health, Boston, MA Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.
Lyn SteffenDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Eric B RimmChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Departments of Nutrition Harvard School of Public Health, Boston, MA Epidemiology, Harvard School of Public Health, Boston, MA.
Frank B HuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Departments of Nutrition Harvard School of Public Health, Boston, MA Epidemiology, Harvard School of Public Health, Boston, MA.
Paul M RidkerDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Institute of Molecular Medicine University of Texas Health Sciences Center-Houston, Houston, TX.
Myriam FornageDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center-Houston, Houston, TX.
Yechiel FriedlanderBraun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Harvard University · USUniversity of Minnesota · USUniversity of Washington · USBrigham and Women's Hospital · USUniversity of Virginia · USCedars-Sinai Medical Center · USHadassah Medical Center · ILKaiser Permanente Washington Health Research Institute · USShanghai Institutes for Biological Sciences · CNThe University of Texas Health Science Center at Houston · USTufts University · USUniversity of Alabama at Birmingham · USUniversity of New Mexico · USUniversity of Sydney · AUVanderbilt University Medical Center · US
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MRISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8MDietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MNCATS NIH HHS UL1 TR000124NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA047988NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004729NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS HL105756NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R00 HL095649NHLBI NIH HHS R00 HL098459NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL060712NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL084099NHLBI NIH HHS R01 HL085710NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL080295NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491
Abstract
Very long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have beneficial biological properties. Whether genetic factors influence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 (SPTLC3), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 (CERS4). The SPTLC3 variant at rs680379 was associated with higher arachidic acid (20:0 , P = 5.81 × 10(-13)). The CERS4 variant at rs2100944 was associated with higher levels of 20:0 (P = 2.65 × 10(-40)) and in analyses that adjusted for 20:0, with lower levels of behenic acid (P = 4.22 × 10(-26)) and lignoceric acid (P = 3.20 × 10(-21)). These novel associations suggest an inter-relationship of circulating VLSFAs and sphingolipid synthesis.
Indexed as
Genetic LociCohort StudiesFatty AcidsGenetic VariationGenome-Wide Association StudyHumansFatty Acidsarachidic acidbehenic acidlignoceric acidsphingolipids
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