ArticleJournal of cancer research and clinical oncology2015
LncRNA and mRNA interaction study based on transcriptome profiles reveals potential core genes in the pathogenesis of human glioblastoma multiforme.
Article in Journal of cancer research and clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
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- Long Non-Coding RNA and mRNA Profiles in the Spinal Cord of Rats with Resiniferatoxin-Induced Neuropathic Pain.Journal of pain research · 2022Article
- Systematic analysis of the long noncoding RNA (lncRNA)-miRNA-mRNA competing endogenous RNA network to identify prognostic biomarkers and the potential regulatory axis in glioblastoma multiforme.Translational cancer research · 2021Article
- LINC00294 induced by GRP78 promotes cervical cancer development by promoting cell cycle transition.Oncology letters · 2020Article
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- Unravelling the role of long non-coding RNA -Non-coding RNA research · 2020Article
- Linc01094 Accelerates the Growth and Metastatic-Related Traits of Glioblastoma by Sponging miR-126-5p.OncoTargets and therapy · 2020Article
- Expression signatures of long non-coding RNA and mRNA in human traumatic brain injury.Neural regeneration research · 2019Article
- Genome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of an lncRNA-mRNA co-expression network.Biology open · 2019Article
- Article
- Analyzing the interactions of mRNAs, miRNAs, lncRNAs and circRNAs to predict competing endogenous RNA networks in glioblastoma.Journal of neuro-oncology · 2018Article
- Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells.Cell death & disease · 2018Article
- Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials.International journal of genomics · 2018Review
- Long non-coding RNAs may serve as biomarkers in breast cancer combined with primary lung cancer.Oncotarget · 2017Article
- Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells.International journal of oncology · 2017Article
- Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study the expression profiles of lncRNA and mRNA in glioblastoma multiforme (GBM) and to find potential core genes in the pathogenesis of this high malignant disease.
methodsAgilent Microarray (Arrystar v2.0) was used to detect the expressions of 33,045 lncRNAs and 30,215 coding transcripts in 5 GBM and 5 normal brain samples. Differentially expressed lncRNAs and mRNAs were identified through Volcano Plot filtering. The expressions of six lncRNAs were further detected by qPCR to validate the results of microarray. The function of differential mRNA was determined by pathway and GO analysis, and the function of lncRNAs was studied by subgroup analysis and by their physical or functional relationships with corresponding mRNAs.
resultsA total of 815 lncRNAs and 738 mRNAs are found to be differentially expressed between the GBM and normal brain groups. With the expression of these differentially expressed genes, the two group samples could be clearly differentiated. The result of qPCR has showed a good consistency with the microarray, thus proving the accuracy of the microarray data. GO and Pathway analyses have proved that the functions of differentially expressed mRNAs in GBM related closely with many processes that important in the cancer pathogenesis. Core lncRNAs and mRNAs that may play important roles in the pathogenesis of GBM are revealed and listed according to various methods.
conclusionThe GBM shows an aberrant expression profile of lncRNA and mRNA. Potential core genes are revealed by the lncRNA and mRNA interaction study based on transcriptome profiles in GBM.
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