ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Permittivity coupling across brain regions determines seizure recruitment in partial epilepsy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- Predicting Surgery Targets in Temporal Lobe Epilepsy through Structural Connectome Based Simulations.PLoS computational biology · 2015Trial
- Seizure recruitment properties are dependent upon dynamotype: A modeling study.PLoS computational biology · 2026Article
- Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone.BMC medicine · 2026Article
- High-resolution Bayesian Virtual Epileptic Patient using neural field models.Network neuroscience (Cambridge, Mass.) · 2026Article
- Article
- Virtual brain twins for stimulation in epilepsy.Nature computational science · 2025Article
- H- and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs.PLoS computational biology · 2025Article
- Controllability of nonlinear epileptic-seizure spreading dynamics in large-scale subject-specific brain networks.Scientific reports · 2025Article
- Bifurcations and bursting in the Epileptor.PLoS computational biology · 2024Article
- An exploratory computational analysis in mice brain networks of widespread epileptic seizure onset locations along with potential strategies for effective intervention and propagation control.Frontiers in computational neuroscience · 2024Article
- Effects of the spatial resolution of the Virtual Epileptic Patient on the identification of epileptogenic networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Brain sodium MRI-derived priors support the estimation of epileptogenic zones using personalized model-based methods in epilepsy.Network neuroscience (Cambridge, Mass.) · 2024Article
- Predicting radiofrequency thermocoagulation surgical outcomes in refractory focal epilepsy patients using functional coupled neural mass model.Frontiers in neurology · 2024Article
- Recent Progress in Brain Network Models for Medical Applications: A Review.Health data science · 2024Review
- Individualized epidemic spreading models predict epilepsy surgery outcomes: A pseudo-prospective study.Network neuroscience (Cambridge, Mass.) · 2024Article
- Epileptic seizure suppression: A computational approach for identification and control using real data.PloS one · 2024Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures.PLoS computational biology · 2023Article
- The role of epidemic spreading in seizure dynamics and epilepsy surgery.Network neuroscience (Cambridge, Mass.) · 2023Article
- The distribution and heterogeneity of excitability in focal epileptic network potentially contribute to the seizure propagation.Frontiers in psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain regions generating seizures in patients with refractory partial epilepsy are referred to as the epileptogenic zone (EZ). During a seizure, paroxysmal activity is not restricted to the EZ, but may recruit other brain regions and propagate activity through large brain networks, which comprise brain regions that are not necessarily epileptogenic. The identification of the EZ is crucial for candidates for neurosurgery and requires unambiguous criteria that evaluate the degree of epileptogenicity of brain regions. To obtain such criteria and investigate the mechanisms of seizure recruitment and propagation, we develop a mathematical framework of coupled neural populations, which can interact via signaling through a slow permittivity variable. The permittivity variable captures effects evolving on slow timescales, including extracellular ionic concentrations and energy metabolism, with time delays of up to seconds as observed clinically. Our analyses provide a set of indices quantifying the degree of epileptogenicity and predict conditions, under which seizures propagate to nonepileptogenic brain regions, explaining the responses to intracerebral electric stimulation in epileptogenic and nonepileptogenic areas. In conjunction, our results provide guidance in the presurgical evaluation of epileptogenicity based on electrographic signatures in intracerebral electroencephalograms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.