ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Millisecond timescale synchrony among hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Physiological landmarks reveal the laminar organization of the primate hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions.eLife · 2026Article
- TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mapping the computational similarity of individual neurons within large-scale ensemble recordings using the SIMNETS analysis framework.Frontiers in neuroscience · 2025Article
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- Cell to network computational model of the epileptic human hippocampus suggests specific roles of network and channel dysfunctions in the ictal and interictal oscillations.Journal of computational neuroscience · 2022Article
- Inhibition allocates spikes during hippocampal ripples.Nature communications · 2022Article
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- Alzheimer's pathology causes impaired inhibitory connections and reactivation of spatial codes during spatial navigation.Cell reports · 2021Article
- Identification and quantification of neuronal ensembles in optical imaging experiments.Journal of neuroscience methods · 2021Article
- Two-Photon Voltage Imaging of Spontaneous Activity from Multiple Neurons Reveals Network Activity in Brain Tissue.iScience · 2020Article
- Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo.Cell reports · 2020Article
- Blocking VEGF by Bevacizumab Compromises Electrophysiological and Morphological Properties of Hippocampal Neurons.Frontiers in cellular neuroscience · 2019Article
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- Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits.Trends in neurosciences · 2018Review
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- Evidence for Long-Timescale Patterns of Synaptic Inputs in CA1 of Awake Behaving Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Multiple Approaches to the Investigation of Cell Assembly in Memory Research-Present and Future.Frontiers in systems neuroscience · 2018Review
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4 authors.
Funding
Abstract
Inhibitory neurons in cortical circuits play critical roles in composing spike timing and oscillatory patterns in neuronal activity. These roles in turn require coherent activation of interneurons at different timescales. To investigate how the local circuitry provides for these activities, we applied resampled cross-correlation analyses to large-scale recordings of neuronal populations in the cornu ammonis 1 (CA1) and CA3 regions of the hippocampus of freely moving rats. Significant counts in the cross-correlation of cell pairs, relative to jittered surrogate spike-trains, allowed us to identify the effective couplings between neurons in CA1 and CA3 hippocampal regions on the timescale of milliseconds. In addition to putative excitatory and inhibitory monosynaptic connections, we uncovered prominent millisecond timescale synchrony between cell pairs, observed as peaks in the central 0 ms bin of cross-correlograms. This millisecond timescale synchrony appeared to be independent of network state, excitatory input, and γ oscillations. Moreover, it was frequently observed between cells of differing putative interneuronal type, arguing against gap junctions as the sole underlying source. Our observations corroborate recent in vitro findings suggesting that inhibition alone is sufficient to synchronize interneurons at such fast timescales. Moreover, we show that this synchronous spiking may cause stronger inhibition and rebound spiking in target neurons, pointing toward a potential function for millisecond synchrony of interneurons in shaping and affecting timing in pyramidal populations within and downstream from the circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.