ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Cerebellar-dependent expression of motor learning during eyeblink conditioning in head-fixed mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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117 citing papers in PubMed.
- Representations of Subsecond Duration-Based Timing by Complex Spike Synchrony in Cerebellar Purkinje Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Unsupervised nonmotor learning in the human cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Neural circuits encode prior knowledge of temporal statistics.Nature neuroscience · 2026Article
- MeCP2 is Necessary in Cerebellar Purkinje Cells for Precise Network Dynamics During Associative Motor Learning.bioRxiv : the preprint server for biology · 2026Article
- Specialized outputs and behavioral contributions of Purkinje cell subtypes.bioRxiv : the preprint server for biology · 2026Article
- Purkinje cell intrinsic activity shapes cerebellar development and function.Nature communications · 2026Article
- Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior.Nature communications · 2026Article
- Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar structure and function abnormalities in 16p11.2 microduplication mice.Brain communications · 2026Article
- Roles for somatostatin and parvalbumin interneurons in learning and arousal during trace conditioning.iScience · 2025Article
- A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Training on multiple days results in better learning in embedded eyeblink conditioning in young human adults.NPJ science of learning · 2025Article
- The effects of P2Y12 loss on microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex.Brain, behavior, and immunity · 2025Article
- Fast implicit and slow explicit learning of temporal context.Scientific reports · 2025Article
- Article
- Neural circuit mechanisms to transform cerebellar population dynamics for motor control in monkeys.bioRxiv : the preprint server for biology · 2025Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- High-resolution awake mouse fMRI at 14 tesla.eLife · 2025Article
- Modulation of cortical representations of sensory and contextual information underlies aversive associative learning.Cell reports · 2024Article
- High-resolution awake mouse fMRI at 14 Tesla.bioRxiv : the preprint server for biology · 2024Article
57 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
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Abstract
Eyeblink conditioning in restrained rabbits has served as an excellent model of cerebellar-dependent motor learning for many decades. In mice, the role of the cerebellum in eyeblink conditioning is less clear and remains controversial, partly because learning appears to engage fear-related circuits and lesions of the cerebellum do not abolish the learned behavior completely. Furthermore, experiments in mice are performed using freely moving systems, which lack the stability necessary for mapping out the essential neural circuitry with electrophysiological approaches. We have developed a novel apparatus for eyeblink conditioning in head-fixed mice. Here, we show that the performance of mice in our apparatus is excellent and that the learned behavior displays two hallmark features of cerebellar-dependent eyeblink conditioning in rabbits: (1) gradual acquisition; and (2) adaptive timing of conditioned movements. Furthermore, we use a combination of pharmacological inactivation, electrical stimulation, single-unit recordings, and targeted microlesions to demonstrate that the learned behavior is completely dependent on the cerebellum and to pinpoint the exact location in the deep cerebellar nuclei that is necessary. Our results pave the way for using eyeblink conditioning in head-fixed mice as a platform for applying next-generation genetic tools to address molecular and circuit-level questions about cerebellar function in health and disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.