ReviewAmerican journal of physiology. Renal physiology2015
The discovery of hypertension: evolving views on the role of the kidneys, and current hot topics.
Review in American journal of physiology. Renal physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Transcriptomic Redox Dysregulation in a Rat Model of Metabolic Syndrome-Associated Kidney Injury.Antioxidants (Basel, Switzerland) · 2025Article
- Evaluation of Oxidative Stress, Anti-Oxidant, Vitamins and Co-Factor Elements in The Sera of Gastric Cancer in Iraqi Patients.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Role of hypertension in progression of pediatric CKD.Pediatric nephrology (Berlin, Germany) · 2023Review
- Ambulatory blood pressure as risk factor for long-term kidney function decline in the general population: a distributional regression approach.Scientific reports · 2023Article
- Epigenetics of the blood pressure reactivity to salt: Is the salt sensitive phenotype correctable?BioImpacts : BI · 2023Article
- Diversified Shifts in the Cross Talk between Members of the Gut Microbiota and Development of Coronary Artery Diseases.Microbiology spectrum · 2022Article
- One-third of patients with lupus nephritis classified as complete responders continue to accrue progressive renal damage despite resolution of proteinuria.Lupus science & medicine · 2022Article
- Uncovering the Complexities of Salt Sensitivity.Function (Oxford, England) · 2022Article
- HIV-positive demonstrate more salt sensitivity and nocturnal non-dipping blood pressure than HIV-negative individuals.Clinical hypertension · 2021Article
- Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Effect of cocoa powder on hypertension and antioxidant status in uninephrectomized hypertensive rats.Veterinary world · 2019Article
- Blood pressure and age-related GFR decline in the general population.BMC nephrology · 2017Article
- Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension?Frontiers in endocrinology · 2017Review
- Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced Hypertension.Circulation · 2016Article
- Vasodysfunction That Involves Renal Vasodysfunction, Not Abnormally Increased Renal Retention of Sodium, Accounts for the Initiation of Salt-Induced Hypertension.Circulation · 2016Review
- Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension.The Journal of clinical investigation · 2015Article
- Gut microbiota in hypertension.Current opinion in nephrology and hypertension · 2015Review
- Effect of febuxostat on renal function in patients from South China with CKD3 diabetic nephropathy.Jornal brasileiro de nefrologiaArticle
- Analogy between non-alcoholic steatohepatitis (NASH) and hypertension: a stepwise patient-tailored approach for NASH treatment.Annals of gastroenterologyReview
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Primary hypertension is increasingly common and is associated with significant morbidity. Here, we review the history of its discovery and rise during the last century with an emphasis on studies trying to identify its cause. Early studies identified a defect in sodium excretion by the kidney as being central to the pathogenesis. Recent studies have focused on a variety of genetic, congenital (fetal programming), and acquired mechanisms for causing the defect in natriuresis. Certain risk factors are apparent, including genetic polymorphisms that regulate sodium excretion, a congenital reduction in nephron number, obesity and hyperleptinemia, an elevated sympathetic nervous system, diet (salt and fructose), and metabolic (hyperuricemia) mechanisms. The kidney shows evidence for renal arteriolar vasoconstriction, an intrarenal inflammatory response, local oxidative stress, and intrarenal activation of the renin-angiotensin system. Recent studies suggest that intrarenal T cells have an important role in causing hypertension to be persistent, likely due to the induction of a local autoimmune response to neoantigens such as heat shock protein 70 and protein aggregates formed by isoketals resulting from lipid peroxidation. Salt retention due to impairment in pressure-diuresis leads to the release of cardiotonic steroids and central nervous system effects that cause systemic vasoconstriction and a rise in blood pressure. Some recent studies suggest that salt may increase blood pressure not simply by effects on extracellular volume but rather as a consequence of hyperosmolarity. These new insights could lead to new approaches for the prevention and treatment of this important disease.
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