ArticleMolecular neurobiology2015
Spontaneous and Partial Repair of Ribbon Synapse in Cochlear Inner Hair Cells After Ototoxic Withdrawal.
Article in Molecular neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- TNF-α impairs the stria vascularis by inducing pericyte apoptosis via the NF-κB pathway in gentamicin-induced hearing loss.Journal of neuroinflammation · 2026Article
- Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice.Science translational medicine · 2024Article
- Multiple Sevoflurane Exposures During the Neonatal Period Cause Hearing Impairment and Loss of Hair Cell Ribbon Synapses in Adult Mice.Frontiers in neuroscience · 2022Article
- Generation and characterization of a P2rx2 V60L mouse model for DFNA41.Human molecular genetics · 2021Article
- Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity.Frontiers in molecular neuroscience · 2021Article
- Syndromic Deafness GeneFrontiers in cell and developmental biology · 2021Article
- Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms.Cold Spring Harbor perspectives in medicine · 2020Review
- Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure.Drug design, development and therapy · 2020Article
- Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss.Neural plasticity · 2020Review
- A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus.Frontiers in neuroscience · 2020Article
- Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.Cold Spring Harbor perspectives in medicine · 2019Review
- N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells.Neural plasticity · 2018Article
- Translational issues in cochlear synaptopathy.Hearing research · 2017Review
- No longer falling on deaf ears: mechanisms of degeneration and regeneration of cochlear ribbon synapses.Hearing research · 2015Review
- Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.Science translational medicine · 2015Article
- Targeting ferroptosis in sensorineural hearing loss: mechanisms, therapeutics, and translational prospects.Frontiers in neurologyReview
- Altered Paired-Click Auditory Brainstem Responses in Normal-Hearing Young Adults With Frequent Loud Sound Exposure.Trends in hearingArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ototoxicity is one of the major causes of sensorineural deafness. However, it remains unclear whether sensorineural deafness is reversible after ototoxic withdrawal. Here, we report that the ribbon synapses between the inner hair cells (IHCs) and spiral ganglion nerve (SGN) fibers can be restored after ototoxic trauma. This corresponds with hearing restoration after ototoxic withdrawal. In this study, adult mice were injected daily with a low dose of gentamicin for 14 consecutive days. Immunostaining for RIBEYE/CtBP2 was used to estimate the number and size of synaptic ribbons in the cochlea. Hearing thresholds were assessed using auditory brainstem responses. Auditory temporal processing between IHCs and SGNs was evaluated by compound action potentials. We found automatic hearing restoration after ototoxicity withdrawal, which corresponded to the number and size recovery of synaptic ribbons, although both hearing and synaptic recovery were not complete. Thus, our study indicates that sensorineural deafness in mice can be reversible after ototoxic withdrawal due to an intrinsic repair of ribbon synapse in the cochlea.
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