ArticleAngewandte Chemie (International ed. in English)2015
A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Keeping an "eye" on the experiment: computer vision for real-time monitoring and control.Chemical science · 2024Article
- Recent advances in catalytic asymmetric synthesis.Frontiers in chemistry · 2024Review
- "Green Is the Color": An Update on Ecofriendly Aspects of Organoselenium Chemistry.Molecules (Basel, Switzerland) · 2022Review
- Review
- Regioselective Magnesiation and Zincation Reactions of Aromatics and Heterocycles Triggered by Lewis Acids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Gram-Scale Domino Synthesis in Batch and Flow Mode of Azetidinium Salts.The Journal of organic chemistry · 2021Article
- Organic Sonochemistry: A Chemist's Timely Perspective on Mechanisms and Reactivity.The Journal of organic chemistry · 2021Article
- Advanced Real-Time Process Analytics for Multistep Synthesis in Continuous Flow*.Angewandte Chemie (International ed. in English) · 2021Article
- Reactor design and selection for effective continuous manufacturing of pharmaceuticals.Journal of flow chemistry · 2021Review
- Automation of Synthesis in Medicinal Chemistry: Progress and Challenges.ACS medicinal chemistry letters · 2020Article
- Toward "On-Demand" Materials Synthesis and Scientific Discovery through Intelligent Robots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications.Molecules (Basel, Switzerland) · 2020Review
- Synthesis of protected glucose derivatives from levoglucosan by development of common carbohydrate protecting group reactions under continuous flow conditions.Carbohydrate research · 2018Article
- Networking chemical robots for reaction multitasking.Nature communications · 2018Article
- Designing Algorithms To Aid Discovery by Chemical Robots.ACS central science · 2018Review
- A Combination of Flow and Batch Mode Processes for the Efficient Preparation of mGluTetrahedron · 2018Article
- The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.Angewandte Chemie (International ed. in English) · 2018Review
- An autonomous organic reaction search engine for chemical reactivity.Nature communications · 2017Article
- Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(spAngewandte Chemie (International ed. in English) · 2016Article
- Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation.Chemical Society reviews · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.