Evidence map›Paper›PMID 25377744›Full record

Observational studyAge and ageing2015

Objectively assessed physical activity and lower limb function and prospective associations with mortality and newly diagnosed disease in UK older adults: an OPAL four-year follow-up study.

Kenneth R Fox, Po-Wen Ku, Melvyn Hillsdon, Mark G Davis, Bethany A J Simmonds, Janice L Thompson, Afroditi Stathi, Selena F Gray, Deborah J Sharp, Joanne C Coulson

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Age and ageing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 7 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 7 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Kenneth R FoxCentre for Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, Avon, UK.
Po-Wen KuGraduate Institute of Sports and Health, National Changhua University of Education, Changhua City, Taiwan.
Melvyn HillsdonDepartment of Sport and Health Sciences, University of Exeter, Exeter, UK.
Mark G DavisCentre for Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, Avon, UK.
Bethany A J SimmondsCentre for Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, Avon, UK.
Janice L ThompsonSchool of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Afroditi StathiDepartment for Health, University of Bath, Bath, UK.
Selena F GrayDepartment of Health and Applied Social Sciences, University of West of England, Bristol, UK.
Deborah J SharpCentre for Academic Primary Health Care, University of Bristol, Bristol, UK.
Joanne C CoulsonCentre for Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, Avon, UK.
University of Bristol · GBNational Changhua University of Education · TWUniversity of Bath · GBUniversity of Birmingham · GBUniversity of Exeter · GBUniversity of the West of England · GB

Funding

British Heart Foundation G0501312Cancer Research UKChief Scientist OfficeDepartment of HealthMedical Research Council G0501312Medical Research Council MR/K00414X/1The Dunhill Medical Trust R200/0511
6 · The paper itself

Abstract

backgroundObjective measures of physical activity and function with a diverse cohort of UK adults in their 70s and 80s were used to investigate relative risk of all-cause mortality and diagnoses of new diseases over a 4-year period.

participantsTwo hundred and forty older adults were randomly recruited from 12 general practices in urban and suburban areas of a city in the United Kingdom. Follow-up included 213 of the baseline sample.

methodsSocio-demographic variables, height and weight, and self-reported diagnosed diseases were recorded at baseline. Seven-day accelerometry was used to assess total physical activity, moderate-to-vigorous activity and sedentary time. A log recorded trips from home. Lower limb function was assessed using the Short Physical Performance Battery. Medical records were accessed on average 50 months post baseline, when new diseases and deaths were recorded. ANALYSES: ANOVAs were used to assess socio-demographic, physical activity and lower limb function group differences in diseases at baseline and new diseases during follow-up. Regression models were constructed to assess the prospective associations between physical activity and function with mortality and new disease.

resultsFor every 1,000 steps walked per day, the risk of mortality was 36% lower (hazard ratios 0.64, 95% confidence interval (CI) 0.44-0.91, P=0.013). Low levels of moderate-to-vigorous physical activity (incident rate ratio (IRR) 1.67, 95% CI 1.04-2.68, P=0.030) and low frequency of trips from home (IRR 1.41, 95% CI 0.98-2.05, P=0.045) were associated with diagnoses of more new diseases.

conclusionPhysical activity should be supported for adults in their 70s and 80s, as it is associated with reduced risk of mortality and new disease development.

Indexed as

AgingHealth StatusMortalityMotor ActivityRisk Reduction BehaviorActigraphyAgedAged, 80 and overAge FactorsDiseaseEnglandExercise TestFemaleFollow-Up StudiesGeriatric AssessmentHealth Behaviormortalitynewly diagnosed diseaseolder adultsphysical activityphysical function

Identifiers

PMID25377744
PMCPMC4339727
OpenAlexW2099810316

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.