ArticleAnnals of neurology2015
Critical role of the right uncinate fasciculus in emotional empathy.
Article in Annals of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Beyond motor: clinical manifestations of right hemisphere gliomas - a systematic review.Journal of neuro-oncology · 2026Pooled it
- White matter abnormalities in tuberous sclerosis complex: a systematic review of diffusion tensor imaging studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- The Role of the Right Language Network and the Multiple-Demand Network in Verbal Semantics: Insights From an Activation Likelihood Estimation Meta-Analysis of 561 Functional Neuroimaging Studies.Human brain mapping · 2025Pooled it
- Facial Emotion Recognition Deficits in Alzheimer's Disease Are Associated With Bilateral Uncinate Fasciculus Abnormalities and Frontotemporal-Limbic Microstructural Disorganisation.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Association Between White Matter Tract Microstructure and Cognitive, Affective, and Somatic Empathy in Children: An Exploratory TRACULA-Based Diffusion MRI Study.Brain and behavior · 2026Article
- Anatomical white matter tracts span the cortical hierarchy to support cognitive diversity.Nature human behaviour · 2026Article
- Neural correlates of social cognition in stroke and traumatic brain injury: A systematic review.Cognitive, affective & behavioral neuroscience · 2026Review
- Body weight-related alterations in white matter functional connectivity in children: An fMRI study.BMC neurology · 2026Article
- Fixel-based analysis reveals detailed white matter changes in semantic dementia.Brain structure & function · 2026Article
- Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity.bioRxiv : the preprint server for biology · 2025Article
- White matter disconnection in acquired criminality.Molecular psychiatry · 2025Article
- Social network size, empathy, and white matter: A diffusion tensor imaging (DTI) study.Cognitive, affective & behavioral neuroscience · 2025Article
- Social cognitive function in stroke survivors: A scoping review.Cerebral circulation - cognition and behavior · 2025Review
- Adapting to Changes in Communication: The Orbitofrontal Cortex in Language and Speech Processing.Brain sciences · 2024Review
- Loss of empathy in stroke.Frontiers in psychology · 2024Article
- Corticolimbic structural connectivity encapsulates real-world emotional reactivity and happiness.Social cognitive and affective neuroscience · 2023Article
- Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.Human brain mapping · 2023Article
- 16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability.Communications biology · 2023Article
- The effect of mindfulness-based intervention on neurobehavioural functioning and its association with white-matter microstructural changes in preterm young adolescents.Scientific reports · 2023Article
- A narrative review of the anatomy and function of the white matter tracts in language production and comprehension.Frontiers in human neuroscience · 2023Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveCommon neurological diseases or injuries that can affect the right hemisphere, including stroke, traumatic brain injury, and frontotemporal dementia, disrupt emotional empathy-the ability to share in and make inferences about how other people feel. This impairment negatively impacts social interactions and relationships. Accumulating evidence indicates that emotional empathy depends on coordinated functions of orbitofrontal cortex, anterior insula, anterior cingulate, temporal pole, and amygdala, but few studies have investigated effects of lesions to white matter tracts that connect these structures. We tested the hypothesis that percentage damage to specific white matter tracts connecting these gray matter structures predicts error rate in an emotional empathy task after acute right hemisphere ischemic stroke.
methodsWe used multivariate linear regression with percentage damage to 8 white matter tracts, age, and education as independent variables and error rate on emotional empathy as the dependent variable to test a predictive model of emotional empathy in 30 patients with acute ischemic right hemisphere stroke.
resultsPercentage damage to 8 white matter tracts along with age and education predicted the error rate in emotional empathy, but only percentage damage to the uncinate fasciculus was independently associated with error rate. Participants with right uncinate fasciculus lesions were significantly more impaired than right hemisphere stroke patients without uncinate fasciculus lesions in the emotional empathy task.
interpretationThe right uncinate fasciculus plays an important role in the emotional empathy network. Patients with lesions in this network should be evaluated for empathy, so that deficits can be addressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.