ArticleDevelopment (Cambridge, England)2014
The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.bioRxiv : the preprint server for biology · 2026Article
- Elucidation of the genetic basis of variation in flowering time in Brassica napus via genome-wide association studies and gene coexpression analysis.BMC plant biology · 2025Article
- Phosphoproteomic analysis of distylous Turnera subulata identifies pathways related to endoreduplication that correlate with reciprocal herkogamy.American journal of botany · 2024Article
- The transcriptome landscape of developing barley seeds.The Plant cell · 2024Article
- PINOID-centered genetic interactions mediate auxin action in cotyledon formation.Plant direct · 2024Review
- Temporal regulation of vegetative phase change in plants.Developmental cell · 2024Review
- Loss-of-function ofPlant signaling & behavior · 2023Article
- PICKLE associates with histone deacetylase 9 to mediate vegetative phase change in Arabidopsis.The New phytologist · 2022Article
- Cdk8 Kinase Module: A Mediator of Life and Death Decisions in Times of Stress.Microorganisms · 2021Review
- Beyond the Genetic Pathways, Flowering Regulation Complexity inInternational journal of molecular sciences · 2021Review
- Functional Analysis ofFrontiers in plant science · 2021Article
- Signal Integration by Cyclin-Dependent Kinase 8 (CDK8) Module and Other Mediator Subunits in Biotic and Abiotic Stress Responses.International journal of molecular sciences · 2020Review
- Juvenile Leaves or Adult Leaves: Determinants for Vegetative Phase Change in Flowering Plants.International journal of molecular sciences · 2020Review
- Characterizing the Role of the miR156-SPL Network in Plant Development and Stress Response.Plants (Basel, Switzerland) · 2020Review
- The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis.Nature communications · 2020Article
- The Important Function of Mediator Complex in Controlling the Developmental Transitions in Plants.International journal of molecular sciences · 2020Review
- The CYCLIN-DEPENDENT KINASE Module of the Mediator Complex Promotes Flowering and Reproductive Development in Pea.Plant physiology · 2020Article
- Loss of function of Oryza sativa Argonaute 18 induces male sterility and reduction in phased small RNAs.Plant reproduction · 2020Article
- The Lifecycle of the Plant Immune System.Critical reviews in plant sciences · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Temporal coordination of developmental programs is necessary for normal ontogeny, but the mechanism by which this is accomplished is still poorly understood. We have previously shown that two components of the Mediator CDK8 module encoded by CENTER CITY (CCT; Arabidopsis MED12) and GRAND CENTRAL (GCT; Arabidopsis MED13) are required for timing of pattern formation during embryogenesis. A morphological, molecular and genomic analysis of the post-embryonic phenotype of gct and cct mutants demonstrated that these genes also promote at least three subsequent developmental transitions: germination, vegetative phase change, and flowering. Genetic and molecular analyses indicate that GCT and CCT operate in parallel to gibberellic acid, a phytohormone known to regulate these same three transitions. We demonstrate that the delay in vegetative phase change in gct and cct is largely due to overexpression of miR156, and that the delay in flowering is due in part to upregulation of FLC. Thus, GCT and CCT coordinate vegetative and floral transitions by repressing the repressors miR156 and FLC. Our results suggest that MED12 and MED13 act as global regulators of developmental timing by fine-tuning the expression of temporal regulatory genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.