ArticleBMC public health2014
The impact of drug use patterns on mortality among polysubstance users in a Canadian setting: a prospective cohort study.
Article in BMC public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Years of Life Lost (YLL) Due to Substance Abuse in Iran, in 2014-2017: Global Burden of Disease 2010 Method.Iranian journal of public health · 2020Article
- Elevated prevalence of self-reported unintentional exposure to fentanyl among women who use drugs in a Canadian setting: A cross-sectional analysis.The International journal on drug policy · 2020Article
- The impact of cocaine and heroin drug history on motivation and cue sensitivity in a rat model of polydrug abuse.Psychopharmacology · 2020Article
- Concurrent Alcohol and Opioid Use Among Harm Reduction Clients.Addictive behaviors · 2020Article
- Supervised injection facility use and all-cause mortality among people who inject drugs in Vancouver, Canada: A cohort study.PLoS medicine · 2019Article
- Integrated Models of Care for People Living with Hepatitis C Virus and a Substance Use Disorder: Protocol for a Systematic Review.JMIR research protocols · 2018Article
- Increasing availability of benzodiazepines among people who inject drugs in a Canadian setting.Substance abuse · 2018Article
- The validity of self-reported drug use with urine test: results from the pilot phase of Azar cohort study.Health promotion perspectives · 2018Article
- Gender differences in patterns of drug use and sexual risky behaviour among crack cocaine users in Central Brazil.BMC psychiatry · 2017Article
- Epidemiological Study of Mortality Rate from Alcohol and Illicit Drug Abuse in Iran.Journal of research in health sciences · 2017Article
- Characterizing Mortality from Substance Abuse in Iran: An Epidemiological Study during March 2014 to February 2015.Addiction & health · 2017Article
- A Hazard Analysis of Risk Factors of Mortality in Individuals Who Inject Drugs in Denver CO.AIDS and behavior · 2017Article
- Reducing rates of preventable HIV/AIDS-associated mortality among people living with HIV who inject drugs.Current opinion in HIV and AIDS · 2016Review
- Sex-Based Differences in Rates, Causes, and Predictors of Death Among Injection Drug Users in Vancouver, Canada.American journal of epidemiology · 2016Article
- Impact of binge alcohol on mortality among people who inject drugs.Addictive behaviors reports · 2015Article
- Mortality from treatable illnesses in marginally housed adults: a prospective cohort study.BMJ open · 2015Article
- The Impact of Benzodiazepine Use on Mortality Among Polysubstance Users in Vancouver, Canada.Public health reports (Washington, D.C. : 1974)Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIllicit drug use is a well-established risk factor for morbidity and mortality. However, few studies have examined the impact of different drug use patterns on mortality among polysubstance using populations. This study aimed to identify drug-specific patterns of mortality among a cohort of polysubstance using persons who inject drugs (PWIDs).
methodsPWIDs in Vancouver, Canada were prospectively followed between May 1996 and December 2011. Participants were linked to the provincial vital statistics database to ascertain mortality rates and causes of death. We used multivariate Cox proportional hazards regression to investigate the relationships between drug use patterns (daily alcohol use, heroin injection and non-injection use, cocaine injection, amphetamine injection and non-injection use, crack smoking and speedball injecting) and time to all-cause mortality.
results2330 individuals were followed for a median of 61 months (inter-quartile range: 33 - 112). In total, 466 (19.1%) individuals died for an incidence density of 3.1 (95% confidence interval [CI]: 2.8 - 3.4) deaths per 100 person-years. In multivariate analyses, after adjusting for HIV infection and other potential confounders, only daily cocaine injection remained independently associated with all-cause mortality (adjusted hazard ratio [AHR] = 1.36, 95% CI: 1.06 - 1.76).
conclusionsAlthough heroin injecting is traditionally viewed as carrying the highest risk of mortality, in this setting, only daily cocaine injecting was associated with all-cause mortality. These findings highlight the urgent need to identify novel treatments and harm reduction strategies for cocaine injectors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.