Evidence map›Paper›PMID 25377237›Full record

ArticlePediatric transplantation2015

Human rhinovirus C infections in pediatric hematology and oncology patients.

Carolina Loria, Jennifer A Domm, Natasha B Halasa, Elizabeth Heitman, E Kathryn Miller, Meng Xu, Benjamin R Saville, Haydar Frangoul, John V Williams

Abstract read
In one paragraph

Article in Pediatric transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Viral Respiratory Infections in Hematological Patients.Infectious diseases and therapy · 2020
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina LoriaCenter for Biomedical Ethics and Society, Vanderbilt University School of Medicine, Nashville, TN, USA.
Jennifer A Domm
Natasha B Halasa
Elizabeth Heitman
E Kathryn Miller
Meng Xu
Benjamin R Saville
Haydar Frangoul
John V Williams

Funding

Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
Host Determinants of Human Metapneumovirus Immunity and PathogenesisR01AI085062 · NIAID · VANDERBILT UNIVERSITY · PI John V. Williams · 2010 to 2026
$5.6M
Creating Collaborative Research Ethics Education with Costa RicaR25TW007697 · FIC · VANDERBILT UNIVERSITY · PI HEITMAN, ELIZABETH · 2006 to 2010
$905k
FIC NIH HHS FIC TW007697FIC NIH HHS R25 TW007697NIAID NIH HHS R01 AI085062NICHD NIH HHS HD043483NICHD NIH HHS K12 HD043483
6 · The paper itself

Abstract

Children with cancer and HSCT recipients are at high risk for common viral infections. We sought to define the viral etiology of ARI and identify risk factors. Nasal wash samples were collected from pediatric hematology-oncology patients and HSCT recipients with ARI during the 2003-2005 winter seasons. Real-time RT-PCR was performed to detect Flu A, influenza B, RSV, PIV 1-3, human MPV, and HRV. HRV specimens were sequenced and genotyped. Seventy-eight samples from 62 children were included. Viruses were detected in 31 of 78 samples (40%). HRV were detected most frequently, in 16 (52%) including five HRVC; followed by seven (22%) RSV, five (16%) Flu A, four (13%) MPV, and two (6%) PIV2. There was a trend toward higher risk of viral infection for children in day care. Only 8% of the study children had received influenza vaccine. HRV, including the recently discovered HRVC, are an important cause of infection in pediatric oncology and HSCT patients. Molecular testing is superior to conventional methods and should be standard of care, as HRV are not detected by conventional methods.

Indexed as

RhinovirusAdolescentChildChild, PreschoolCommon ColdFemaleHematologic DiseasesHematopoietic Stem Cell TransplantationHumansInfantInfluenza, HumanMaleNeoplasmsRetrospective StudiesRisk FactorsYoung Adultcancerhuman rhinoviruspediatricreal-time reverse transcription polymerase chain reactionrespiratory viruses

Identifiers

PMID25377237
PMCPMC4280346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.