ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015
Platelet-rich plasma for open meniscal repair in young patients: any benefit?
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02872753 (Intra-operative ACP Injection Following Partial Meniscectomy), which is not on this map. Cited by 58 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intra-operative ACP Injection Following Partial Meniscectomy: a Randomized Controlled Trial
Who cites it
58 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- No evidence in support of arthroscopic partial meniscectomy in adults with degenerative and nonobstructive meniscal symptoms: a level I evidence-based systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies.Journal of orthopaedic surgery and research · 2022Pooled it
- Biological augmentation of meniscal repair: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Platelet-rich plasma (PRP) augmentation does not result in more favourable outcomes in arthroscopic meniscal repair: a meta-analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2022Pooled it
- Clinical efficacy of platelet-rich plasma as adjuvant therapy in patients undergoing arthroscopic repair of meniscal injury.The Journal of international medical research · 2020Pooled it
- The repair of horizontal cleavage tears yields higher complication rates compared to meniscectomy: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Pooled it
- Meniscus Repair and Regeneration: A Systematic Review from a Basic and Translational Science Perspective.Clinics in sports medicine · 2020Pooled it
- A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma.BioMed research international · 2018Trial
- Evaluation of Spin Bias in the Use of Platelet-Rich Plasma for Augmentation of Meniscal Tear Repairs.Orthopaedic journal of sports medicine · 2026Review
- Systematic reviews in PRP-augmented meniscal repair have limited methodological quality: A systematic overview.Journal of experimental orthopaedics · 2026Article
- Platelet-rich plasma facilitates earlier functional recovery and return to sport in traumatic meniscal repair: a retrospective cohort study.Journal of orthopaedic surgery and research · 2026Article
- Rethinking meniscal repair in patients over 40: Extending the boundaries of joint preservation.World journal of methodology · 2026Review
- Management of Horizontal Cleavage Meniscus Tears.Current reviews in musculoskeletal medicine · 2025Review
- Ultrasound-guided injection using leucocyte-rich platelet-rich plasma for treatment of meniscal injuries in a duathlete: a case report.Regenerative medicine · 2024Article
- How to Improve Meniscal Repair through Biological Augmentation: A Narrative Review.Journal of clinical medicine · 2024Review
- Efficacy of Intraoperative Platelet-Rich Plasma After Meniscal Repair: Systematic Review and Meta-analysis.Indian journal of orthopaedics · 2024Review
- Horizontal Cleavage Meniscus Tear: "The Quad Tendon Augmentation Technique".Arthroscopy techniques · 2024Article
- Platelet-rich plasma and other injectables in the young athlete.Journal of the Pediatric Orthopaedic Society of North America · 2024Review
- Comparative, Controlled, Retrospective Study of Patient-Reported Outcomes After Meniscectomy With Adjunctive Use of Platelet-Rich Plasma or Amniotic Umbilical Cord Tissue.Ochsner journal · 2024Article
- Effect of anti-inflammatory treatments on patient outcomes and concentrations of inflammatory modulators in the post-surgical and post-traumatic tibiofemoral joint setting: a narrative review.Annals of joint · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMany studies have demonstrated that injection of various growth factors including platelet-derived growth factor could increase meniscal cell activity and stimulate repair. The purpose of this study was to augment repair and promote meniscal healing by the use of platelet-rich plasma (PRP) within horizontal cleavage meniscal tears repaired via an open approach. The hypothesis was that the clinical outcomes and healing process would be improved using this meniscal healing augmentation technique.
methodsIn this case-control study, 34 consecutive young patients underwent an open meniscal repair to treat symptomatic Grade 2 or Grade 3 horizontal meniscal tears [median age 28 years (13-40)]. The median time between the onset of symptoms and surgery was 11.5 months (6-50). In the first group (17 consecutive patients, Group 1), a standard open meniscal repair was performed. In the second group (17 consecutive patients, Group 2), the same surgical repair was performed, but platelet-rich plasma was introduced into the lesion at the end of the procedure. Clinical outcomes were evaluated using KOOS and IKDC 2000 scores. MRI was performed at 1 year after surgery for objective evaluation.
resultsAt a minimum of 24 months postoperatively (mean 32.2 months, 24-40), three patients underwent subsequent meniscectomy (two in Group 1, one in Group 2). The mean KOOS distribution (pain, symptoms, daily activities, sports, quality of life) was 78.4, 86.1, 93.8, 74.4, 74.6 in Group 1, and 93.3, 90.7, 97.1, 88.8, 78.3 in Group 2 (p < 0.05 for pain and sports parameters). MRI revealed five cases with the complete disappearance of any hypersignal within the repaired meniscus in Group 2, and none in Group 1 (p < 0.01).
conclusionsOpen meniscal repair of horizontal tears extending into the avascular zone was effective at midterm follow-up in young patients. Clinical outcomes were slightly improved by the addition of PRP in this case-control study. LEVEL OF EVIDENCE: III.
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Registered trials
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