ReviewStem cells (Dayton, Ohio)2015
Concise reviews: Assisted reproductive technologies to prevent transmission of mitochondrial DNA disease.
Review in Stem cells (Dayton, Ohio), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Fetal and obstetrics manifestations of mitochondrial diseases.Journal of translational medicine · 2024Review
- Review
- Endocrine Manifestations and New Developments in Mitochondrial Disease.Endocrine reviews · 2022Article
- Mitochondrial donation: is Australia ready?The Medical journal of Australia · 2022Article
- Advanced tools and methods for single-cell surgery.Microsystems & nanoengineering · 2022Review
- Review
- Review
- Three-parent babies: Mitochondrial replacement therapies.JBRA assisted reproduction · 2020Review
- Assessing mitochondrial heteroplasmy using next generation sequencing: A note of caution.Mitochondrion · 2019Article
- Public attitudes towards novel reproductive technologies: a citizens' jury on mitochondrial donation.Human reproduction (Oxford, England) · 2019Article
- Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome.Essays in biochemistry · 2018Review
- Mitochondrial Disease: Advances in clinical diagnosis, management, therapeutic development, and preventative strategies.Current genetic medicine reports · 2018Article
- Recent developments in genetics and medically assisted reproduction: from research to clinical applications.European journal of human genetics : EJHG · 2018Review
- Recent developments in genetics and medically-assisted reproduction: from research to clinical applicationsHuman reproduction open · 2017Article
- Toward a therapy for mitochondrial disease.Biochemical Society transactions · 2016Review
- Mitochondrial donation and 'the right to know'.Journal of medical ethics · 2016Article
- Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.Nature · 2016Article
- Ethical and legal issues in mitochondrial transfer.EMBO molecular medicine · 2016Article
- Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells.Cell metabolism · 2016Article
- Modifying the Mitochondrial Genome.Cell metabolism · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
While the fertilized egg inherits its nuclear DNA from both parents, the mitochondrial DNA is strictly maternally inherited. Cells contain multiple copies of mtDNA, each of which encodes 37 genes, which are essential for energy production by oxidative phosphorylation. Mutations can be present in all, or only in some copies of mtDNA. If present above a certain threshold, pathogenic mtDNA mutations can cause a range of debilitating and fatal diseases. Here, we provide an update of currently available options and new techniques under development to reduce the risk of transmitting mtDNA disease from mother to child. Preimplantation genetic diagnosis (PGD), a commonly used technique to detect mutations in nuclear DNA, is currently being offered to determine the mutation load of embryos produced by women who carry mtDNA mutations. The available evidence indicates that cells removed from an eight-cell embryo are predictive of the mutation load in the entire embryo, indicating that PGD provides an effective risk reduction strategy for women who produce embryos with low mutation loads. For those who do not, research is now focused on meiotic nuclear transplantation techniques to uncouple the inheritance of nuclear and mtDNA. These approaches include transplantation of any one of the products or female meiosis (meiosis II spindle, or either of the polar bodies) between oocytes, or the transplantation of pronuclei between fertilized eggs. In all cases, the transferred genetic material arises from a normal meiosis and should therefore, not be confused with cloning. The scientific progress and associated regulatory issues are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.