ArticleBiomicrofluidics2014
Changes in velocity profile according to blood viscosity in a microchannel.
Article in Biomicrofluidics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Repeatability and reliability of retinal arterial hemodynamics measurement using Doppler holography.Journal of biomedical optics · 2026Article
- A Novel CTC-Binding Probe: Enzymatic vs. Shear Stress-Based Detachment Approaches.Diagnostics (Basel, Switzerland) · 2025Article
- Sticking together: Polymerization of sickle hemoglobin drives the multiscale pathophysiology of sickle cell disease.Biophysics reviews · 2025Review
- Microparticle electrical conductivity measurement using optoelectronic tweezers.Journal of applied physics · 2023Article
- iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays.Nature communications · 2023Article
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- Active Opto-Magnetic Biosensing with Silicon Microring Resonators.Sensors (Basel, Switzerland) · 2022Article
- Design of a Portable Microfluidic Platform for EGOT-Based in Liquid Biosensing.Sensors (Basel, Switzerland) · 2022Article
- Rapid determination of erythrocyte sedimentation rate (ESR) by an electrically driven blood droplet biosensor.Biomicrofluidics · 2020Article
- Influence of Hydrodynamics and Hematocrit on Ultrasound-Induced Blood Plasmapheresis.Micromachines · 2020Article
- Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows.Micromachines · 2019Article
- Hemostasis-On-a-Chip: Impedance Spectroscopy Meets Microfluidics for Hemostasis Evaluation.Micromachines · 2019Article
- Investigation of Micro-volume Viscosity with Janus Microbeads Based on Rotational Brownian Motion.Sensors (Basel, Switzerland) · 2019Article
- Article
- Periodic and simultaneous quantification of blood viscosity and red blood cell aggregation using a microfluidic platform underBiomicrofluidics · 2018Article
- Red blood cell (RBC) suspensions in confined microflows: Pressure-flow relationship.Medical engineering & physics · 2017Article
- Microfluidic-Based Measurement Method of Red Blood Cell Aggregation under Hematocrit Variations.Sensors (Basel, Switzerland) · 2017Article
- Microfluidic system for monitoring temporal variations of hemorheological properties and platelet adhesion in LPS-injected rats.Scientific reports · 2017Article
- Microfluidic measurement for blood flow and platelet adhesion around a stenotic channel: Effects of tile size on the detection of platelet adhesion in a correlation map.Biomicrofluidics · 2017Article
- Variation in wall shear stress in channel networks of zebrafish models.Journal of the Royal Society, Interface · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Red blood cells (RBCs) are important to dictate hemorheological properties of blood. The shear-thinning effect of blood is mainly attributed to the characteristics of the RBCs. Variations in hemorheological properties alter flow resistance and wall shear stress in blood vessels. Therefore, detailed understanding of the relationship between the hemorheological and hemodynamic properties is of great importance. In this study, blood viscosity and blood flow were simultaneously measured in the same microfluidic device by monitoring the flow-switching phenomenon. To investigate blood flows according to hemorheological variations, the flow rate of blood samples (RBCs suspended in autologous plasma, dextran-treated plasma, and in phosphate buffered saline solution) was precisely controlled with a syringe pump. Velocity profiles of blood flows were measured by using a micro-particle imagevelocimetry technique. The shape of velocity profiles was quantified by using a curve-fitting equation. It is found that the shape of the velocity profiles is highly correlated with blood viscosity. To demonstrate the relationship under ex vivo conditions, biophysical properties and velocity profiles were measured in an extracorporeal rat bypass loop. Experimental results show that increased blood viscosity seems to induce blunt velocity profile with high velocity component at the wall of the microchannel. Simultaneous measurement of blood viscosity and velocity profile would be useful for understanding the effects of hemorheological features on the hemodynamic characteristics in capillary blood vessels.
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Registered trials
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