ArticleScientific reports2014
Novel mutations and mutation combinations of ryanodine receptor in a chlorantraniliprole resistant population of Plutella xylostella (L.).
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 171 citations in OpenAlex.
- Resistance monitoring and putative biochemical mechanisms of Spodoptera frugiperda to different insecticides in China.Pest management science · 2026Article
- The diversity of insecticide target site mutations in Apis mellifera.BMC genomics · 2026Article
- Molecular Insights into the Action Mechanism, Resistance Development, and Ecological Risks of Cyantraniliprole.International journal of molecular sciences · 2026Review
- Whole-genome sequencing reveals novel ryanodine receptor mutations P4568L and Y4701D conferring high-level chlorantraniliprole resistance in Spodoptera litura (Lepidoptera: Noctuidae).Pest management science · 2026Article
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- Quantitative genetic analysis of diamide resistance in Australian Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae).Scientific reports · 2025Article
- The Evolution of Pesticide Resistance: A Data-Driven Case Study of Chlorantraniliprole Resistance inEvolutionary applications · 2025Review
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- Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance.Nature communications · 2024Article
- Effects ofInsects · 2024Article
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- Functional Characterization of the Ryanodine Receptor Gene inLife (Basel, Switzerland) · 2022Article
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- Genome-Wide Scans and Transcriptomic Analyses Characterize Selective Changes as a Result of Chlorantraniliprole Resistance inInternational journal of molecular sciences · 2022Article
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- Diamide insecticide resistance in transgenic Drosophila and Sf9-cells expressing a full-length diamondback moth ryanodine receptor carrying an I4790M mutation.Pest management science · 2022Article
- A mechanism-based approach unveils metabolic routes potentially mediating chlorantraniliprole synergism in honey bees, Apis mellifera L., by azole fungicides.Pest management science · 2022Article
- Chemosensory Proteins Are Associated with Thiamethoxam and Spirotetramat Tolerance inInternational journal of molecular sciences · 2022Article
- Genome-wide identification and functional analysis of long non-coding RNAs inFrontiers in physiology · 2022Article
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A previous study documented a glycine to glutamic acid mutation (G4946E) in ryanodine receptor (RyR) was highly correlated to diamide insecticide resistance in field populations of Plutella xylostella (Lepidoptera: Plutellidae). In this study, a field population collected in Yunnan province, China, exhibited a 2128-fold resistance to chlorantraniliprole. Sequence comparison between resistant and susceptible P. xylostella revealed three novel mutations including a glutamic acid to valine substitution (E1338D), a glutamine to leucine substitution (Q4594L) and an isoleucine to methionine substitution (I4790M) in highly conserved regions of RyR. Frequency analysis of all four mutations in this field population showed that the three new mutations showed a high frequency of 100%, while the G4946E had a frequency of 20%. Furthermore, the florescent ligand binding assay revealed that the RyR containing multiple mutations displayed a significantly lower affinity to the chlorantraniliprole. The combined results suggested that the co-existence of different combinations of the four mutations was involved in the chlorantraniliprole resistance. An allele-specific PCR based method was developed for the diagnosis of the four mutations in the field populations of P. xylostella.
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