Evidence map›Paper›PMID 25376808›Full record

ArticleAJNR. American journal of neuroradiology2015

Impact of time-to-reperfusion on outcome in patients with poor collaterals.

Y-H Hwang, D-H Kang, Y-W Kim, Y-S Kim, S-P Park, D S Liebeskind

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Relative cerebral blood volume is associated with collateral status and infarct growth in stroke patients in SWIFT PRIME.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
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  7. The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - anInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
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  13. Association of pre-mechanical thrombectomy collateral scores with functional outcomes in the early versus extended window for thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Y-H HwangFrom the Departments of Neurology (Y.-H.H., Y.-W.K., S.-P.P.) Cerebrovascular Center (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K.), Kyungpook National University Hospital, Daegu, Korea School of Medicine (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K., S.-P.P.), Kyungpook National University, Daegu, Korea yangha.hwang@gmail.com.ORCID http://orcid.org/0000-0002-6665-7481
D-H KangNeurosurgery (D.-H.K.) Radiology (D.-H.K., Y.-W.K., Y.-S.K.) Cerebrovascular Center (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K.), Kyungpook National University Hospital, Daegu, Korea School of Medicine (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K., S.-P.P.), Kyungpook National University, Daegu, Korea.
Y-W KimFrom the Departments of Neurology (Y.-H.H., Y.-W.K., S.-P.P.) Radiology (D.-H.K., Y.-W.K., Y.-S.K.) Cerebrovascular Center (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K.), Kyungpook National University Hospital, Daegu, Korea School of Medicine (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K., S.-P.P.), Kyungpook National University, Daegu, Korea.
Y-S KimRadiology (D.-H.K., Y.-W.K., Y.-S.K.) Cerebrovascular Center (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K.), Kyungpook National University Hospital, Daegu, Korea School of Medicine (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K., S.-P.P.), Kyungpook National University, Daegu, Korea.
S-P ParkFrom the Departments of Neurology (Y.-H.H., Y.-W.K., S.-P.P.) School of Medicine (Y.-H.H., D.-H.K., Y.-W.K., Y.-S.K., S.-P.P.), Kyungpook National University, Daegu, Korea.
D S LiebeskindUCLA Stroke Center (D.S.L.), University of California, Los Angeles, Los Angeles, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe relationship between reperfusion and clinical outcome is time-dependent, and the effect of reperfusion on outcome can vary on the basis of the extent of collateral flow. We aimed to identify the impact of time-to-reperfusion on outcome relative to baseline angiographic collateral grade in patients successfully treated with endovascular revascularization for acute large-vessel anterior circulation stroke. MATERIALS AND

methodsTwo hundred seven patients were selected for analysis from our prospectively maintained registry. Inclusion criteria were M1 MCA ± ICA occlusions, onset-to-puncture time within 8 hours, and successful endovascular reperfusion. Baseline angiographic collateral grades were independently evaluated and dichotomized into poor (0-1) versus good (2-4). Multivariable analyses were performed to identify the effect of collateral-flow adequacy on favorable outcome on the basis of onset-to-reperfusion time and puncture-to-reperfusion time.

resultsIn the poor collateral group, the odds of favorable outcome significantly dropped for patients with onset-to-reperfusion time of >300 minutes or puncture-to-reperfusion time of >60 minutes (onset-to-puncture time: ≤300, 59% versus >300, 32%; OR, 0.24; P = .011; puncture-to-reperfusion time: ≤60, 73% versus >60, 32%; OR, 0.21, P = .011), whereas the probability of favorable outcome in the good collateral group was not significantly influenced by onset-to-reperfusion time or puncture-to-reperfusion time. In the subgroup lesion-volume growth analysis by using DWI, the effect of puncture-to-reperfusion time of >60 minutes was significantly greater compared with the effect of puncture-to-reperfusion time of <60 minutes in the poor collateral group (β = 41.6 cm(3), P = .001).

conclusionsTime-to-reperfusion including onset-to-reperfusion time and puncture-to-reperfusion time in patients with poor collaterals is an important limiting factor for favorable outcome in a time-dependent fashion. Future trials may benefit from a noninvasive imaging technique to detect poor collaterals along with a strategy for rapid reperfusion.

Indexed as

Collateral CirculationReperfusionTime-to-TreatmentAgedBrain InfarctionFemaleHumansMaleMiddle AgedStroke

Identifiers

PMID25376808
PMCPMC8013039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.