Evidence map›Paper›PMID 25376788›Full record

ArticleJournal of neurophysiology2015

Isn't functional neuroimaging all about Ca2+ signaling in astrocytes?

Mauro DiNuzzo

Abstract readComment
In one paragraph

Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Mauro DiNuzzoMuseo storico della fisica e Centro di studi e ricerche "Enrico Fermi," Rome, Italy; and Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy mauro.dinuzzo@neuroenergetics.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extensive research over the past decades about the multifaceted roles of brain astrocytes led to the suggestion that the signals observed with functional neuroimaging might primarily reflect astrocytic rather than neuronal activity. The basis for this paradigm-shifting concept was the evidence for an involvement of astrocytes in the control of local cerebral blood flow through intracellular Ca(2+) signaling. In this Neuro Forum, I discuss new important experimental findings obtained by Jego et al. (Jego P, Pacheco-Torres J, Araque A, Canals S. J Cereb Blood Flow Metab 34: 1599-1603, 2014) as well as other closely related studies published recently, prompting a dismissal of substantial astrocytic contribution in functional neuroimaging.

Indexed as

Calcium SignalingPerforant PathwayAnimalsAstrocytesHippocampusInositol 1,4,5-Trisphosphate ReceptorsMaleInositol 1,4,5-Trisphosphate Receptorsastrocytic Ca2+ signalingneurovascular coupling

Identifiers

PMID25376788
PMCPMC4556851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.