ReviewClinical journal of the American Society of Nephrology : CJASN2015
AKI associated with cardiac surgery.
Review in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 5 syntheses or guidelines pooled it, 308 citations in OpenAlex.
- Efficacy of N-acetylcysteine in Preventing Acute Kidney Injury and Major Adverse Cardiac Events After Cardiac Surgery: A Meta-Analysis and Trial Sequential Analysis.Frontiers in medicine · 2022Pooled it
- Timing of initiation of renal replacement therapy in acute kidney injury: an updated meta-analysis of randomized controlled trials.Renal failure · 2020Pooled it
- Association of postoperative fluid overload with adverse outcomes after congenital heart surgery: a systematic review and dose-response meta-analysis.Pediatric nephrology (Berlin, Germany) · 2020Pooled it
- Age and Surgical Complexity impact on Renoprotection by Remote Ischemic Preconditioning during Adult Cardiac Surgery: A Meta analysis.Scientific reports · 2017Pooled it
- Pooled it
- Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.Circulation · 2024Trial
- Effect of Ascorbic Acid on Cardiac Surgery-Associated Acute Kidney Injury Incidence.The Thoracic and cardiovascular surgeon · 2022Trial
- A randomized double-blind, placebo-controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA-230 during experimental human endotoxaemia.British journal of clinical pharmacology · 2019Trial
- Safety of a Restrictive versus Liberal Approach to Red Blood Cell Transfusion on the Outcome of AKI in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.Journal of the American Society of Nephrology : JASN · 2019Trial
- Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery.Scientific reports · 2019Trial
- Perioperative THR-184 and AKI after Cardiac Surgery.Journal of the American Society of Nephrology : JASN · 2018Trial
- Kidney Failure in Cardiogenic Shock.Circulation. Heart failure · 2026Review
- Article
- Amino acids for the prevention of acute kidney injury after cardiac surgery: a narrative review of trials and meta-analyses.Journal of cardiothoracic surgery · 2026Review
- Fluid balance during PICU stay in children after cardiac surgery with cardiopulmonary bypass.European journal of pediatrics · 2026Article
- Kidney Volume as a Predictor and Modifier of Acute Kidney Injury with Renin-Angiotensin System Inhibitors.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Severity matters: reframing cardiac surgery-associated acute kidney injury.Critical care science · 2026Article
- A new category for understanding the mechanisms of drug-induced kidney injury.Renal failure · 2025Review
- Comparable renal effects of histidine-tryptophan-ketoglutarate and DelNido cardioplegia in a porcine model of cardiac arrest.Renal failure · 2025Article
- Iron-related protein in prediction of acute kidney injury in the pediatric population after cardiac surgery.Journal of cardiothoracic surgery · 2025Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 18% of patients undergoing cardiac surgery experience AKI (on the basis of modern standardized definitions of AKI), and approximately 2%-6% will require hemodialysis. The development of AKI after cardiac surgery portends poor short- and long-term prognoses, with those developing RIFLE failure or AKI Network stage III having an almost 2-fold increase in the risk of death. AKI is caused by a variety of factors, including nephrotoxins, hypoxia, mechanical trauma, inflammation, cardiopulmonary bypass, and hemodynamic instability, and it may be affected by the clinician's choice of fluids and vasoactive agents as well as the transfusion strategy used. The risk of AKI may be ameliorated by avoidance of nephrotoxins, achievement of adequate glucose control preoperatively, and use of goal-directed therapy hemodynamic strategies. Remote ischemic preconditioning is an exciting future strategy, but more work is needed before widespread implementation. Unfortunately, there are no pharmacologic agents known to reduce the risk of AKI or treat established AKI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.