ArticleJournal of dental research2015
Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium.
Article in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Metagenome and Metabolic Pathways in Plaque Biofilms of Thai ELANE-Associated Neutropenic Patients: An Original Study and Scoping Review.European journal of dentistry · 2026Article
- Salivary Proteomic Signatures Reveal Novel Mechanistic Insights into Moderate Dental Fluorosis Pathogenesis and Oral Homeostasis Disruption.Computational and structural biotechnology journal · 2026Article
- Analysis of MSX1, RYK, NFκB p65, and CCL4 Proteins andInternational journal of molecular sciences · 2025Article
- KDF1 promotes ameloblast differentiation by inhibiting the IKK/IκB/NF-κB axis.Journal of cellular physiology · 2024Article
- DPP promotes odontogenic differentiation of DPSCs through NF-κB signaling.Scientific reports · 2021Article
- Article
- Evaluating the Expression of Candidate Homeobox Genes and Their Role in Local-Site Inflammation in Mucosal Tissue Obtained from Children with Non-Syndromic Cleft Lip and Palate.Journal of personalized medicine · 2021Article
- Role of Cell Death in Cellular Processes During Odontogenesis.Frontiers in cell and developmental biology · 2021Review
- ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.Autophagy · 2020Article
- IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.International journal of oral science · 2020Article
- Process of ectopic tooth formation in the maxillary sinus: follow-up observation of one case.The Journal of international medical research · 2019Article
- Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells.Stem cell research & therapy · 2019Article
- The epidemiology of supernumerary teeth and the associated molecular mechanism.Organogenesis · 2017Review
- Early epithelial signaling center governs tooth budding morphogenesis.The Journal of cell biology · 2016Article
- Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors.European journal of oral sciences · 2015Article
Corrections and comments
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Authors and funding
26 authors at 13 institutions in 8 countries.
Funding
Abstract
Nuclear factor kappa B (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-κB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKβ, an essential component of the NF-κB pathway, under keratin 5 promoter (K5-Ikkβ). K5-Ikkβ mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkβ mice. The supernumerary incisors in K5-Ikkβ mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-κB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.
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Registered trials
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