ArticleInternational journal of obesity (2005)2014
Reference values of bone stiffness index and C-terminal telopeptide in healthy European children.
Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
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- Early Castration in Horses Does Not Impact Osteoarticular Metabolism.International journal of molecular sciences · 2023Article
- Hand grip strength, vitamin D status, and diets as predictors of bone health in 6-12 years old school children.BMC musculoskeletal disorders · 2023Observational
- Cross-sectional and longitudinal associations between physical activity, sedentary behaviour and bone stiffness index across weight status in European children and adolescents.The international journal of behavioral nutrition and physical activity · 2020Article
- A novel mutation inGenes & diseases · 2019Article
- Assessment of Biochemical Bone Turnover Markers and Bone Mineral Density in Thin and Normal-Weight Children.Cartilage · 2018Article
- Physical activity may be a potent regulator of bone turnover biomarkers in healthy girls during preadolescence.Journal of bone and mineral metabolism · 2017Article
- Unusually High Calcaneal Speed of Sound Measurements in Children with Small Foot Size.Ultrasound in medicine & biology · 2017Article
- Urinary Mineral Concentrations in European Pre-Adolescent Children and Their Association with Calcaneal Bone Quantitative Ultrasound Measurements.International journal of environmental research and public health · 2016Article
- Impact of physical activity, sedentary behaviour and muscle strength on bone stiffness in 2-10-year-old children-cross-sectional results from the IDEFICS study.The international journal of behavioral nutrition and physical activity · 2015Article
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Authors and funding
12 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveQuantitative ultrasound measurements and bone metabolic markers can help to monitor bone health and to detect impaired skeletal development. Population-based reference values for children may serve as a basis for preventive measures to reduce the risk of osteoporosis and osteoporotic fractures in later life. This is the first paper providing age-, sex- and height-specific reference values for bone stiffness index (SI) and serum carboxy-terminal cross-linking telopeptide of type I collagen (CTX) in healthy, apparently prepubertal children. SUBJECTS/
methodsIn the population-based IDEFICS baseline survey (2007-2008) and follow-up (2009-2010), 18,745 children from eight European countries were newly recruited. A total of 10,791 2-10.9-year-old and 1646 3-8.9-year-old healthy children provided data on SI of the right and left calcaneus and serum CTX, respectively. Furthermore, height and weight were measured. Percentile curves were calculated using the General Additive Model for Location Scale and Shape (GAMLSS) to model the distribution of SI and CTX depending on multiple covariates while accounting for dispersion, skewness, and the kurtosis of this distribution.
resultsSI was negatively associated with age and height in children aged 2-5 years, whereas a positive association was observed in children aged 6-10 years. The dip in SI occurred at older age for higher SI percentiles and was observed earlier in taller children than in smaller children. The CTX reference curves showed a linear-positive association with age and height. No major sex differences were observed for the SI and CTX reference values.
conclusionThese reference data lay the ground to evaluate bone growth and metabolism in prepubertal children in epidemiological and clinical settings. They may also inform clinical practice to monitor skeletal development and to assess adverse drug reactions during medical treatments.
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