ArticlePloS one2014
Oxygen pathway modeling estimates high reactive oxygen species production above the highest permanent human habitation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Delivery Systems for Plasma-reactive Species and their Applications in the Field of Biomedicine.Current drug delivery · 2024Review
- Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives.EXCLI journal · 2020Article
- Risk and temporal order of disease diagnosis of comorbidities in patients with COPD: a population health perspective.BMJ open respiratory research · 2018Article
- Stress injuries and autophagy in mouse hippocampus after chronic cold exposure.Neural regeneration research · 2017Article
- Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach.Bioinformatics (Oxford, England) · 2017Article
- Mitochondrial function at extreme high altitude.The Journal of physiology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
The production of reactive oxygen species (ROS) from the inner mitochondrial membrane is one of many fundamental processes governing the balance between health and disease. It is well known that ROS are necessary signaling molecules in gene expression, yet when expressed at high levels, ROS may cause oxidative stress and cell damage. Both hypoxia and hyperoxia may alter ROS production by changing mitochondrial Po2 (PmO2). Because PmO2 depends on the balance between O2 transport and utilization, we formulated an integrative mathematical model of O2 transport and utilization in skeletal muscle to predict conditions to cause abnormally high ROS generation. Simulations using data from healthy subjects during maximal exercise at sea level reveal little mitochondrial ROS production. However, altitude triggers high mitochondrial ROS production in muscle regions with high metabolic capacity but limited O2 delivery. This altitude roughly coincides with the highest location of permanent human habitation. Above 25,000 ft., more than 90% of exercising muscle is predicted to produce abnormally high levels of ROS, corresponding to the "death zone" in mountaineering.
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Registered trials
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