ArticlePloS one2014
The positive regulatory roles of the TIFY10 proteins in plant responses to alkaline stress.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 80 citations in OpenAlex.
- Genome-Wide Identification and Expressional Analysis of theInternational journal of molecular sciences · 2025Article
- Genome-Wide Identification of the TIFY Family in Longan and Their Potential Functional Analysis in Anthocyanin Synthesis.Biology · 2025Article
- The Impact of Alkaline Stress on Plant Growth and Its Alkaline Resistance Mechanisms.International journal of molecular sciences · 2024Review
- Genome-wide identification, characterization and expression pattern analysis of TIFY family members in Artemisia argyi.BMC genomics · 2024Article
- Transcriptome analysis reveals biosynthesis and regulation of flavonoid in common bean seeds during grain filling.BMC plant biology · 2024Article
- Genome-wide identification and expression analysis of the Eriobotrya japonica TIFY gene family reveals its functional diversity under abiotic stress conditions.BMC genomics · 2024Article
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- Decrypting Molecular Mechanisms Involved in Counteracting Copper and Nickel Toxicity in Jack Pine (Plants (Basel, Switzerland) · 2024Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2024Article
- The miRNA-mRNA regulatory networks of the response to NaHCOBMC plant biology · 2023Article
- Integrated Multi-Omics Reveals Significant Roles of Non-Additively Expressed Small RNAs in Heterosis for Maize Plant Height.International journal of molecular sciences · 2023Article
- Genome-wide identification of the TIFY family reveals JAZ subfamily function in response to hormone treatment in Betula platyphylla.BMC plant biology · 2023Article
- Gene Expression Analysis of Potato (Plants (Basel, Switzerland) · 2022Article
- Genome-wide identification and expression of TIFY family in cassava (Frontiers in plant science · 2022Article
- Article
- Insights into the regulation of wild soybean tolerance to salt-alkaline stress.Frontiers in plant science · 2022Review
- Genome-Wide Analysis of the Soybean TIFY Family and Identification ofFrontiers in plant science · 2022Article
- Citric Acid-Mediated Abiotic Stress Tolerance in Plants.International journal of molecular sciences · 2021Review
- From Spaceflight to MarsInternational journal of molecular sciences · 2021Article
- New Insights Into Structure and Function ofFrontiers in genetics · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TIFY family is a novel plant-specific protein family, and is characterized by a conserved TIFY motif (TIFF/YXG). Our previous studies indicated the potential roles of TIFY10/11 proteins in plant responses to alkaline stress. In the current study, we focused on the regulatory roles and possible physiological and molecular basis of the TIFY10 proteins in plant responses to alkaline stress. We demonstrated the positive function of TIFY10s in alkaline responses by using the AtTIFY10a and AtTIFY10b knockout Arabidopsis, as evidenced by the relatively lower germination rates of attify10a and attify10b mutant seeds under alkaline stress. We also revealed that ectopic expression of GsTIFY10a in Medicago sativa promoted plant growth, and increased the NADP-ME activity, citric acid content and free proline content but decreased the MDA content of transgenic plants under alkaline stress. Furthermore, expression levels of the stress responsive genes including NADP-ME, CS, H+-ppase and P5CS were also up-regulated in GsTIFY10a transgenic plants under alkaline stress. Interestingly, GsTIFY10a overexpression increased the jasmonate content of the transgenic alfalfa. In addition, we showed that neither GsTIFY10a nor GsTIFY10e exhibited transcriptional activity in yeast cells. However, through Y2H and BiFc assays, we demonstrated that GsTIFY10a, not GsTIFY10e, could form homodimers in yeast cells and in living plant cells. As expected, we also demonstrated that GsTIFY10a and GsTIFY10e could heterodimerize with each other in both yeast and plant cells. Taken together, our results provided direct evidence supporting the positive regulatory roles of the TIFY10 proteins in plant responses to alkaline stress.
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