ArticlePloS one2014
Virulence diversity among bacteremic Aeromonas isolates: ex vivo, animal, and clinical evidences.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A Systematic Review of Culture-Based Methods for Monitoring Antibiotic-Resistant Acinetobacter, Aeromonas, and Pseudomonas as Environmentally Relevant Pathogens in Wastewater and Surface Water.Current environmental health reports · 2023Pooled it
- Managing Pneumonia Due to Rare Non-Fermenting Gram-Negative Bacteria: Epidemiology, Risk Factors and Therapeutic Strategies.Antibiotics (Basel, Switzerland) · 2026Review
- Article
- Genomic insights intoFrontiers in microbiology · 2026Article
- Review
- Virulence Genes and Antimicrobial Resistance Profiles inMicroorganisms · 2025Article
- Age-Dependent Variations in the Distribution ofPathogens (Basel, Switzerland) · 2025Article
- Whole-genome sequencing-based species classification, multilocus sequence typing, and antibiotic resistance mechanisms of the clinicalFrontiers in microbiology · 2025Article
- Aeromonas veronii-associated bacteremia in the course of treatment of acute myeloid leukemia: a case report and review of the literature.Discover oncology · 2024Article
- A case report of severe pneumonia caused byFrontiers in medicine · 2024Article
- Case Report: A rare infection of multidrug-resistantFrontiers in pediatrics · 2024Article
- A 26-year-old man with multiple organ failure caused byFrontiers in medicine · 2024Article
- Multidrug-resistant Aeromonas bacteria prevalence in Nile tilapia broodstock.BMC microbiology · 2023Article
- Identification and characterization of a novel 6'-N-aminoglycoside acetyltransferase AAC(6')-Va from a clinical isolate ofFrontiers in microbiology · 2023Article
- Epidemiology ofMicroorganisms · 2022Article
- Complexation of a Polypeptide-Polyelectrolytes Bioparticle as a Biomaterial of Antibacterial Activity.Pharmaceutics · 2022Article
- Taxonomy, virulence determinants and antimicrobial susceptibility of Aeromonas spp. isolated from bacteremia in southeastern China.Antimicrobial resistance and infection control · 2021Article
- UvrY is required for the full virulence ofVirulence · 2020Article
- An Update on the GenusMicroorganisms · 2020Review
- Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to compare virulence among different Aeromonas species causing bloodstream infections. METHODOLOGY/PRINCIPAL
findingsNine of four species of Aeromonas blood isolates, including A. dhakensis, A. hydrophila, A. veronii and A. caviae were randomly selected for analysis. The species was identified by the DNA sequence matching of rpoD. Clinically, the patients with A. dhakensis bacteremia had a higher sepsis-related mortality rate than those with other species (37.5% vs. 0%, P = 0.028). Virulence of different Aeromonas species were tested in C. elegans, mouse fibroblast C2C12 cell line and BALB/c mice models. C. elegans fed with A. dhakensis and A. caviae had the lowest and highest survival rates compared with other species, respectively (all P values <0.0001). A. dhakensis isolates also exhibited more cytotoxicity in C2C12 cell line (all P values <0.0001). Fourteen-day survival rate of mice intramuscularly inoculated with A. dhakensis was lower than that of other species (all P values <0.0001). Hemolytic activity and several virulence factor genes were rarely detected in the A. caviae isolates. CONCLUSIONS/SIGNIFICANCE: Clinical data, ex vivo experiments, and animal studies suggest there is virulence variation among clinically important Aeromonas species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.