ArticlePloS one2014
Transcriptomic profiling of gametogenesis in triploid Pacific Oysters Crassostrea gigas: towards an understanding of partial sterility associated with triploidy.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Growth-Linked, Tissue-Specific Antioxidant Reprogramming During Natural Zn/Cu Bioaccumulation in the Pacific OysterAntioxidants (Basel, Switzerland) · 2026Article
- Metabolic reprogramming and mitochondrial dysfunction underlie β gonia arrest and niche cell dysfunction in sterile triploid oysters.Communications biology · 2025Article
- Transcriptomic Analysis Reveals the Growth Regulatory Mechanisms in Diploid, Triploid, and Tetraploid Pacific Oyster (Animals : an open access journal from MDPI · 2025Article
- Effects of salinity on pre- and post-fertilization developmental events in the clamAnimal reproduction · 2023Article
- Relationship between Condition Index Values and Expression Levels of Gene and Protein in the Adductor Muscle of Diploid and Triploid OystersDevelopment & reproduction · 2022Article
- Male triploid oysters of Crassostrea gigas exhibit defects in mitosis and meiosis during early spermatogenesis.FEBS open bio · 2022Article
- Genome-Wide Differential DNA Methylomes Provide Insights into the Infertility of Triploid Oysters.Marine biotechnology (New York, N.Y.) · 2022Article
- Transcription Analysis for Core Networks of lncRNAs-mRNAs: Implication for Potential Role in Sterility ofBiology · 2022Article
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- Transcriptome Profiling of the Pacific OysterMarine drugs · 2021Article
- Biomphalaria glabrata immunity: Post-genome advances.Developmental and comparative immunology · 2020Review
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- The flagellar protein Enkurin is required for mouse sperm motility and for transport through the female reproductive tract.Biology of reproduction · 2018Article
- GigaTON: an extensive publicly searchable database providing a new reference transcriptome in the pacific oyster Crassostrea gigas.BMC bioinformatics · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTriploidy can occur in many animal species but is often lethal. Among invertebrates, amphibians and fishes, triploids are viable although often sterile or infertile. Most triploids of the Pacific oyster Crassostrea gigas are almost sterile (named "3nβ") yet a low but significant proportion show an advanced gametogenesis (named "3nα"). These oysters thus constitute an interesting model to study the effect of triploidy on germ cell development. We used microarrays to compare the gonad transcriptomes of diploid 2n and the abovementioned triploid 3nβ and 3nα male and female oysters throughout gametogenesis.
resultsAll triploids displayed an upregulation of genes related to DNA repair and apoptosis and a downregulation of genes associated with cell division. The comparison of 3nα and 3nβ transcriptomes with 2n revealed the likely involvement of a cell cycle checkpoint during mitosis in the successful but delayed development of gonads in 3nα individuals. In contrast, a disruption of sex differentiation mechanisms may explain the sterility of 3nβ individuals with 3nβ females expressing male-specific genes and 3nβ males expressing female-specific genes.
conclusionsThe disruption of sex differentiation and mitosis may be responsible for the impaired gametogenesis of triploid Pacific oysters. The function of the numerous candidate genes identified in our study should now be studied in detail in order to elucidate their role in sex determination, mitosis/meiosis control, pachytene cell cycle checkpoint, and the control of DNA repair/apoptosis.
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