ArticleNutrients2014
Oxidative damage and inflammation in obese diabetic Emirati subjects.
Article in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- A randomized, double-blind, placebo-controlled trial of vitamin D supplementation with or without calcium in community-dwelling vitamin D deficient subjects.BMC musculoskeletal disorders · 2022Trial
- The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain.Journal of diabetes research · 2016Trial
- Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study.Nutrients · 2015Trial
- A Systematized Review of the Relationship Between Obesity and Vitamin C Requirements.Current developments in nutrition · 2024Review
- Article
- Urinary Oxidative Damage Markers and Their Association with Obesity-Related Metabolic Risk Factors.Antioxidants (Basel, Switzerland) · 2022Article
- Vitamin D deficiency associations with metabolic, bone turnover and adverse general health markers in community free living adults.BMC endocrine disorders · 2022Article
- Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study.BMJ open gastroenterology · 2020Article
- Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators.Saudi journal of biological sciences · 2020Review
- Sexual Dimorphism in Cardiovascular Disease Risk and Risk Factors Among Vegetarians: an Exploration of the Potential Mechanisms.Current atherosclerosis reports · 2019Review
- Total adiponectin in overweight and obese subjects and its response to visceral fat loss.BMC endocrine disorders · 2019Article
- Efficacy of Alpha-lipoic Acid in The Management of Diabetes Mellitus: A Systematic Review and Meta-analysis.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Positively increased visceral adiposity index in hyperuricemia free of metabolic syndrome.Lipids in health and disease · 2018Article
- Obesity moderates the complex relationships between inflammation, oxidative stress, sleep quality and depressive symptoms.BMC obesity · 2018Article
- Oxidative damage and associated inflammatory risk factors in obese Emirati women. Body mass index versus waist circumference.Saudi medical journal · 2017Article
- Gender-specific association of oxidative stress and inflammation with cardiovascular risk factors in Arab population.Mediators of inflammation · 2015Article
- Anti-Inflammatory Effects of Ang-(1-7) in Ameliorating HFD-Induced Renal Injury through LDLr-SREBP2-SCAP Pathway.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visceral obesity is more common in the Arab population and more closely related to morbidity, including diabetes and related cardiovascular diseases (CVD). Possible mechanisms that link visceral fat/obesity to diabetes and CVD complications include inflammation and increased oxidative stress; however, few data are available from the Arab population. Our aim was to determine whether increased adiposity in obese diabetic United Arab Emirates citizens is associated with sub-clinical inflammation and/or increased oxidative stress. A hundred diabetic patients who were part of a randomized controlled trial of nutritional supplements had their baseline characteristics assessed from anthropometric and clinical data following informed written consent. We used WHO figures to classify general and central obesity. Fasting blood samples were collected for the measurement of antioxidants and markers of oxidative damage and inflammation. We found that increased adiposity measured by both body mass index and waist circumference was associated with increased C-reactive protein (CRP) and decreased vitamin C after adjusting for age, duration and treatment of diabetes (p < 0.05). Although there is a clear trend of increased inflammatory markers, notably CRP, and decreased antioxidants with increased BMI and waist circumference in both men and women, the results are statistically significant for women only. CRP were also inversely associated with HDL. Overall, we found that BMI underestimates the rates of obesity compared to waist circumference and that increased adiposity is associated with increased inflammation and decreased HDL and antioxidant status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.