ArticlePLoS genetics2014
Genomic evidence of rapid and stable adaptive oscillations over seasonal time scales in Drosophila.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 277 papers, 1 of them a synthesis that pooled it.
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Who cites it
277 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A cosmopolitan inversion facilitates seasonal adaptation in overwintering Drosophila.Genetics · 2024Pooled it
- Natural Variation in Drosophila melanogaster Clock PolyQ Length: Geographic Gradients and Functional Properties.Molecular ecology · 2026Article
- Article
- Dissecting Fluctuating Selection: A Unified Population and Quantitative Genetics Framework.Genome biology and evolution · 2026Article
- Article
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Non-uniform chromosomal SNP density biases sites of meiotic crossovers in Drosophila melanogaster.G3 (Bethesda, Md.) · 2026Article
- Realization of ongoing evolutionary adaptation in the field.Evolution letters · 2026Article
- Climate predictsbioRxiv : the preprint server for biology · 2026Article
- The geometry of dominance shows broad potential for stable polymorphism under antagonistic pleiotropy.bioRxiv : the preprint server for biology · 2026Article
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Genetic Footprints of Seasonal Fluctuating Selection: A Comparison With Established Selection Forms.Genome biology and evolution · 2026Article
- Seasonal fluctuations in fitness result in severe reductions in effective population size.bioRxiv : the preprint server for biology · 2026Article
- Rapid adaptation and extinction in synchronized outdoor evolution experiments ofScience (New York, N.Y.) · 2026Article
- Evolution of phenotypic plasticity owing to migration.Evolution letters · 2026Article
- Overwintering drives rapid adaptation in Drosophila with potential costs to insecticide resistance.Evolution; international journal of organic evolution · 2026Article
- Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Non-uniform chromosomal SNP density biases sites of meiotic crossovers inbioRxiv : the preprint server for biology · 2025Article
- Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes.Evolution letters · 2025Article
- Variation in the resource environment affects patterns of seasonal adaptation at phenotypic and genomic levels inEvolution letters · 2025Article
217 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
In many species, genomic data have revealed pervasive adaptive evolution indicated by the fixation of beneficial alleles. However, when selection pressures are highly variable along a species' range or through time adaptive alleles may persist at intermediate frequencies for long periods. So called "balanced polymorphisms" have long been understood to be an important component of standing genetic variation, yet direct evidence of the strength of balancing selection and the stability and prevalence of balanced polymorphisms has remained elusive. We hypothesized that environmental fluctuations among seasons in a North American orchard would impose temporally variable selection on Drosophila melanogaster that would drive repeatable adaptive oscillations at balanced polymorphisms. We identified hundreds of polymorphisms whose frequency oscillates among seasons and argue that these loci are subject to strong, temporally variable selection. We show that these polymorphisms respond to acute and persistent changes in climate and are associated in predictable ways with seasonally variable phenotypes. In addition, our results suggest that adaptively oscillating polymorphisms are likely millions of years old, with some possibly predating the divergence between D. melanogaster and D. simulans. Taken together, our results are consistent with a model of balancing selection wherein rapid temporal fluctuations in climate over generational time promotes adaptive genetic diversity at loci underlying polygenic variation in fitness related phenotypes.
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