ArticleMolecules (Basel, Switzerland)2014
Antifungal activity and computational study of constituents from Piper divaricatum essential oil against Fusarium infection in black pepper.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Antifungal Potential ofPlants (Basel, Switzerland) · 2025Article
- A simple and reliable QSPR model for prediction of chromatography retention indices of volatile organic compounds in peppers.RSC advances · 2024Article
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- Anti-proliferative Activity ofCombinatorial chemistry & high throughput screening · 2023Article
- Essential Oil of the Plants Growing in the Brazilian Amazon: Chemical Composition, Antioxidants, and Biological Applications.Molecules (Basel, Switzerland) · 2022Review
- Plant-Derived Protectants in Combating Soil-Borne Fungal Infections in Tomato and Chilli.Journal of fungi (Basel, Switzerland) · 2022Review
- Secondary Metabolic Profile as a Tool for Distinction and Characterization of Cultivars of Black Pepper (International journal of molecular sciences · 2021Article
- Artocarpus altilis extracts as a food-borne pathogen and oxidation inhibitors: RSM, COSMO RS, and molecular docking approaches.Scientific reports · 2020Article
- Antimicrobial, Cytotoxic, and Anti-Inflammatory Activities ofBioMed research international · 2019Article
- Essential Oils from Neotropical Piper Species and Their Biological Activities.International journal of molecular sciences · 2017Review
- Antifungal Activity of Thapsia villosa Essential Oil against Candida, Cryptococcus, Malassezia, Aspergillus and Dermatophyte Species.Molecules (Basel, Switzerland) · 2017Article
- Composition of Asarum heterotropoides var. mandshuricum radix oil from different extraction methods and activities against human body odor-producing bacteria.Journal of food and drug analysis · 2016Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium disease causes considerable losses in the cultivation of Piper nigrum, the black pepper used in the culinary world. Brazil was the largest producer of black pepper, but in recent years has lost this hegemony, with a significant reduction in its production, due to the ravages produced by the Fusarium solani f. sp. piperis, the fungus which causes this disease. Scientific research seeks new alternatives for the control and the existence of other Piper species in the Brazilian Amazon, resistant to disease, are being considered in this context. The main constituents of the oil of Piper divaricatum are methyleugenol (75.0%) and eugenol (10.0%). The oil and these two main constituents were tested individually at concentrations of 0.25 to 2.5 mg/mL against F. solani f. sp. piperis, exhibiting strong antifungal index, from 18.0% to 100.0%. The 3D structure of the β-glucosidase from Fusarium solani f. sp. piperis, obtained by homology modeling, was used for molecular docking and molecular electrostatic potential calculations in order to determine the binding energy of the natural substrates glucose, methyleugenol and eugenol. The results showed that β-glucosidase (Asp45, Arg113, Lys146, Tyr193, Asp225, Trp226 and Leu99) residues play an important role in the interactions that occur between the protein-substrate and the engenol and methyleugenol inhibitors, justifying the antifungal action of these two phenylpropenes against Fusarium solani f. sp. piperis.
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