ArticlePloS one2014
Sensitivity and specificity of point-of-care rapid combination syphilis-HIV-HCV tests.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Independent clinic-based evaluation of dual POCTs for screening for HIV and syphilis in men who have sex with men in Italy, Malta, Peru, and the United Kingdom.BMC infectious diseases · 2024Pooled it
- Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis.Sexually transmitted infections · 2022Pooled it
- A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis.Sexually transmitted infections · 2017Pooled it
- Diagnostic accuracy of tests to detect Hepatitis C antibody: a meta-analysis and review of the literature.BMC infectious diseases · 2017Pooled it
- Missed Opportunities for Human Immunodeficiency Virus and Syphilis Testing Among Men Who Have Sex With Men in China: A Cross-Sectional Study.Sexually transmitted diseases · 2018Trial
- How to Use Rapid Dual Treponemal and Lipoidal Tests in Clinical Practice.Sexually transmitted diseases · 2026Article
- Laboratory Evaluation of the Chembio DPP Syphilis Screen & Confirm Point-of-Care Test on Serum and Simulated Blood Samples.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
- Point-of-Care Diagnostics for Diagnosis of Active Syphilis Infection: Needs, Challenges and the Way Forward.International journal of environmental research and public health · 2022Article
- Laboratory Evaluation of the DPP Syphilis Screen & Confirm Assay.Microbiology spectrum · 2022Article
- Canadian Public Health Laboratory Network guidelines for the use of point-of-care tests forJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2022Article
- Stopping syphilis transmission in Arctic communities through rapid diagnostic testing: The STAR study protocol.PloS one · 2022Article
- Comparative evaluation of three rapid immunochromatographic test assays with chemiluminescent microparticle immunoassay for the detection of hepatitis C virus antibody.Virusdisease · 2019Article
- Field performance evaluation of dual rapid HIV and syphilis tests in three antenatal care clinics in Zambia.International journal of STD & AIDS · 2019Article
- A latent class analysis of alcohol and drug use immediately before or during sex among women.The American journal of drug and alcohol abuse · 2019Article
- Article
- An evaluation of the SD Bioline HIV/syphilis duo test.International journal of STD & AIDS · 2018Article
- Laboratory Evaluation of a Smartphone-Based Electronic Reader of Rapid Dual Point-of-Care Tests for Antibodies to Human Immunodeficiency Virus and Treponema pallidum Infections.Sexually transmitted diseases · 2017Article
- Laboratory Evaluation of a Point-of-Care Downward-Flow Assay for Simultaneous Detection of Antibodies to Treponema pallidum and Human Immunodeficiency Virus.Journal of clinical microbiology · 2016Article
- Syphilis: Re-emergence of an old foe.Microbial cell (Graz, Austria) · 2016Review
- Laboratory Evaluation of a Dual-Path Platform Assay for Rapid Point-of-Care HIV and Syphilis Testing.Journal of clinical microbiology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundNew rapid point-of-care (POC) tests are being developed that would offer the opportunity to increase screening and treatment of several infections, including syphilis. This study evaluated three of these new rapid POC tests at a site in Southern California.
methodsParticipants were recruited from a testing center in Long Beach, California. A whole blood specimen was used to evaluate the performance of the Dual Path Platform (DPP) Syphilis Screen & Confirm, DPP HIV-Syphilis, and DPP HIV-HCV-Syphilis rapid tests. The gold-standard comparisons were Treponema pallidum passive particle agglutination (TPPA), rapid plasma reagin (RPR), HCV enzyme immunoassay (EIA), and HIV-1/2 EIA.
resultsA total of 948 whole blood specimens were analyzed in this study. The sensitivity of the HIV tests ranged from 95.7-100% and the specificity was 99.7-100%. The sensitivity and specificity of the HCV test were 91.8% and 99.3%, respectively. The treponemal-test sensitivity when compared to TPPA ranged from 44.0-52.7% and specificity was 98.7-99.6%. The non-treponemal test sensitivity and specificity when compared to RPR was 47.8% and 98.9%, respectively. The sensitivity of the Screen & Confirm test improved to 90.0% when cases who were both treponemal and nontreponemal positive were compared to TPPA+/RPR ≥ 1 ∶ 8.
conclusionsThe HIV and HCV on the multi-infection tests showed good performance, but the treponemal and nontreponemal tests had low sensitivity. These results could be due to a low prevalence of active syphilis in the sample population because the sensitivity improved when the gold standard was limited to those more likely to be active cases. Further evaluation of the new syphilis POC tests is required before implementation into testing programs.
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