ArticlePLoS genetics2014
A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Unveiling Van Der Waals Forces and Associated Hamaker Constants Across the Nanomaterial Landscape With Advanced Atomic Force Microscopy.Small methods · 2026Review
- DCAF2 regulates the proliferation and differentiation of mouse progenitor spermatogonia by targeting p21 and thymine DNA glycosylase.Cell proliferation · 2024Article
- Epigenetic Regulation in Uterine Fibroids-The Role of Ten-Eleven Translocation Enzymes and Their Potential Therapeutic Application.International journal of molecular sciences · 2022Review
- Olaparib-mediated enhancement of 5-fluorouracil cytotoxicity in mismatch repair deficient colorectal cancer cells.BMC cancer · 2021Article
- Effect of the thymine-DNA glycosylase rs4135050 variant on Saudi smoker population.Molecular genetics & genomic medicine · 2019Article
- SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation.The EMBO journal · 2019Article
- TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study.Journal of oncology · 2019Article
- Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes.Environmental and molecular mutagenesis · 2017Article
- How does inflammation drive mutagenesis in colorectal cancer?Trends in cancer research · 2017Article
- Mechanisms of glycosylase induced genomic instability.PloS one · 2017Article
- Base Excision Repair Variants in Cancer.Methods in enzymology · 2017Article
- Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.Molecular cancer research : MCR · 2016Article
- Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination.Molecular pharmacology · 2016Article
- Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis.Acta biochimica et biophysica Sinica · 2016Review
- Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer.Journal of Cancer · 2016Review
- Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites.DNA repair · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-FU) paired with adenine or guanine. The rs4135113 single nucleotide polymorphism (SNP) of TDG is found in 10% of the global population. This coding SNP results in the alteration of Gly199 to Ser. Gly199 is part of a loop responsible for stabilizing the flipped abasic nucleotide in the active site pocket. Biochemical analyses indicate that G199S exhibits tighter binding to both its substrate and abasic product. The persistent accumulation of abasic sites in cells expressing G199S leads to the induction of double-strand breaks (DSBs). Cells expressing the G199S variant also activate a DNA damage response. When expressed in cells, G199S induces genomic instability and cellular transformation. Together, these results suggest that individuals harboring the G199S variant may have increased risk for developing cancer.
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