ArticleAmerican journal of clinical and experimental urology2014
A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds.
Article in American journal of clinical and experimental urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Evaluation of prostate cancer detection using micro-ultrasound versus MRI through co-registration to whole-mount pathology.Scientific reports · 2024Article
- Preoperative imaging accuracy in size determination of prostate cancer in men undergoing radical prostatectomy for clinically localised disease.Insights into imaging · 2023Article
- 3D Printed Personalized Medicine for Cancer: Applications for Betterment of Diagnosis, Prognosis and Treatment.AAPS PharmSciTech · 2021Review
- Registration of histopathology to magnetic resonance imaging of prostate cancer.Physics and imaging in radiation oncology · 2021Article
- ProsRegNet: A deep learning framework for registration of MRI and histopathology images of the prostate.Medical image analysis · 2021Article
- Variability in accuracy of prostate cancer segmentation among radiologists, urologists, and scientists.Cancer medicine · 2020Article
- Three-dimensional printing versus conventional machining in the creation of a meatal urethral dilator: development and mechanical testing.Biomedical engineering online · 2020Article
- Multi-colour extrusion fused deposition modelling: a low-cost 3D printing method for anatomical prostate cancer models.Scientific reports · 2020Article
- How else can we approach prostate cancer biomarker discovery?Expert review of molecular diagnostics · 2020Article
- Innovation in Urology: Three Dimensional Printing and Its Clinical Application.Frontiers in surgery · 2020Review
- MR Imaging-Histology Correlation by Tailored 3D-Printed Slicer in Oncological Assessment.Contrast media & molecular imaging · 2019Review
- Registration Accuracy of Patient-Specific, Three-Dimensional-Printed Prostate Molds for Correlating Pathology With Magnetic Resonance Imaging.IEEE transactions on bio-medical engineering · 2019Article
- Radiological Society of North America (RSNA) 3D printing Special Interest Group (SIG): guidelines for medical 3D printing and appropriateness for clinical scenarios.3D printing in medicine · 2018Article
- Accurate validation of ultrasound imaging of prostate cancer: a review of challenges in registration of imaging and histopathology.Journal of ultrasound · 2018Review
- 3D printing in urology: Is it really promising?Turkish journal of urology · 2018Review
- Improved Magnetic Resonance Imaging-Pathology Correlation With Imaging-Derived, 3D-Printed, Patient-Specific Whole-Mount Molds of the Prostate.Investigative radiology · 2017Article
- Co-Registration of ex vivo Surgical Histopathology and in vivo T2 weighted MRI of the Prostate via multi-scale spectral embedding representation.Scientific reports · 2017Article
- Combined T2 and diffusion-weighted MR imaging with template prostate biopsies in men suspected with prostate cancer but negative transrectal ultrasound-guided biopsies.World journal of urology · 2017Article
- Magnetic Resonance Imaging Underestimation of Prostate Cancer Geometry: Use of Patient Specific Molds to Correlate Images with Whole Mount Pathology.The Journal of urology · 2017Article
- Biofabrication and biomaterials for urinary tract reconstruction.Research and reports in urology · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
We have developed a system for evaluating magnetic resonance imaging of prostate cancer, using patient-specific 3D printed molds to facilitate MR-histology correlation. Prior to radical prostatectomy a patient receives a multiparametric MRI, which an expert genitourinary radiologist uses to identify and contour regions suspicious for disease. The same MR series is used to generate a prostate contour, which is the basis for design of a patient-specific mold. The 3D printed mold contains a series of evenly spaced parallel slits, each of which corresponds to a known MRI slice. After surgery, the patient's specimen is enclosed within the mold, and all whole-mount levels are obtained simultaneously through use of a multi-bladed slicing device. The levels are then formalin fixed, processed, and delivered to an expert pathologist, who identifies and grades all lesions within the slides. Finally, the lesion contours are loaded into custom software, which elastically warps them to fit the MR prostate contour. The suspicious regions on MR can then be directly compared to lesions on histology. Furthermore, the false-negative and false-positive regions on MR can be retrospectively examined, with the ultimate goal of developing methods for improving the predictive accuracy of MRI. This work presents the details of our analysis method, following a patient from diagnosis through the MR-histology correlation process. For this patient MRI successfully predicted the presence of cancer, but true lesion volume and extent were underestimated. Most cancer-positive regions missed on MR were observed to have patterns of low T2 signal, suggesting that there is potential to improve sensitivity.
Indexed as
Identifiers
25374914PMC4219304What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.